A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole

BACKGROUND AND OBJECTIVE: Hydatidosis is possible in all organs. However, brain involvement is only observed in only 1-2% of patients and is very rare. Common symptoms of brain involvement include headache, vomiting, seizures, behavioral disorders, or unilateral symptoms such as paralysis of one hal...

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Autores principales:	E Vafadar Moradi, M Talebi Doluee, B Rezavani Kakhki, B Abbasi, B Chaeedeh, H Baharvahdat
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	seizures cerebral hydatidosis albendazole phenytoin. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4746612ee5d949a8adbf03bba7f0caff
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spelling	oai:doaj.org-article:4746612ee5d949a8adbf03bba7f0caff2021-11-09T10:15:55ZA Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole1561-41072251-7170https://doaj.org/article/4746612ee5d949a8adbf03bba7f0caff2020-03-01T00:00:00Zhttp://jbums.org/article-1-9148-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Hydatidosis is possible in all organs. However, brain involvement is only observed in only 1-2% of patients and is very rare. Common symptoms of brain involvement include headache, vomiting, seizures, behavioral disorders, or unilateral symptoms such as paralysis of one half of the body. Here we present a patient with cerebral hydatidosis that has recurred due to drug interactions between phenytoin and albendazole. CASE REPORT: The patient is a 19 -year- old man with a history of cerebral hydatidosis who underwent two surgeries with complaints of generalized tonic-clonic seizures. CT scan of the brain showed a lobule cyst with internal septa in the right hemisphere of the brain with an adjacent lesion that has wall calcification, suggesting cerebral hydatidosis. To control the patient s seizures, sodium valproate was substituted for phenytoin and oral albendazole was recommended in consultation with the Infectious Diseases Service. The patient was discharged after five days in good general condition. CONCLUSION: According to this case, concomitant use of anticonvulsant drugs including phenytoin, phenobarbital, and carbamazepine with albendazole has been reported to reduce plasma levels of albendazole and reduce its efficacy. Therefore, to control seizures in patients with cerebral hydatidosis treated with albendazole, it is better to use other anticonvulsant drugs.E Vafadar MoradiM Talebi DolueeB Rezavani KakhkiB AbbasiB ChaeedehH BaharvahdatBabol University of Medical Sciencesarticleseizurescerebral hydatidosisalbendazolephenytoin.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 304-307 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	seizures cerebral hydatidosis albendazole phenytoin. Medicine R Medicine (General) R5-920
spellingShingle	seizures cerebral hydatidosis albendazole phenytoin. Medicine R Medicine (General) R5-920 E Vafadar Moradi M Talebi Doluee B Rezavani Kakhki B Abbasi B Chaeedeh H Baharvahdat A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole
description	BACKGROUND AND OBJECTIVE: Hydatidosis is possible in all organs. However, brain involvement is only observed in only 1-2% of patients and is very rare. Common symptoms of brain involvement include headache, vomiting, seizures, behavioral disorders, or unilateral symptoms such as paralysis of one half of the body. Here we present a patient with cerebral hydatidosis that has recurred due to drug interactions between phenytoin and albendazole. CASE REPORT: The patient is a 19 -year- old man with a history of cerebral hydatidosis who underwent two surgeries with complaints of generalized tonic-clonic seizures. CT scan of the brain showed a lobule cyst with internal septa in the right hemisphere of the brain with an adjacent lesion that has wall calcification, suggesting cerebral hydatidosis. To control the patient s seizures, sodium valproate was substituted for phenytoin and oral albendazole was recommended in consultation with the Infectious Diseases Service. The patient was discharged after five days in good general condition. CONCLUSION: According to this case, concomitant use of anticonvulsant drugs including phenytoin, phenobarbital, and carbamazepine with albendazole has been reported to reduce plasma levels of albendazole and reduce its efficacy. Therefore, to control seizures in patients with cerebral hydatidosis treated with albendazole, it is better to use other anticonvulsant drugs.
format	article
author	E Vafadar Moradi M Talebi Doluee B Rezavani Kakhki B Abbasi B Chaeedeh H Baharvahdat
author_facet	E Vafadar Moradi M Talebi Doluee B Rezavani Kakhki B Abbasi B Chaeedeh H Baharvahdat
author_sort	E Vafadar Moradi
title	A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole
title_short	A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole
title_full	A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole
title_fullStr	A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole
title_full_unstemmed	A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole
title_sort	case report of recurrent cerebral hydatid cyst; interaction between phenytoin and albendazole
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/4746612ee5d949a8adbf03bba7f0caff
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A Case Report of Recurrent Cerebral Hydatid Cyst; Interaction between Phenytoin and Albendazole

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