Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature

Background: Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 in...

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Autores principales:	Michelangelo La Placa, Riccardo Balestri, Federico Tartari, Andrea Sechi, Francesca Ferrara, Camilla Loi, Annalisa Patrizi, Federico Bardazzi
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	mucous membrane pemphigoid malignancy autoimmune bullous disorders paraneoplastic pemphigus laminin-332 blistering diseases Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/474f09521900426fa62198dbd21969a6
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spelling	oai:doaj.org-article:474f09521900426fa62198dbd21969a62021-11-17T08:29:32ZMucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature10.5826/dpc.0902a072160-9381https://doaj.org/article/474f09521900426fa62198dbd21969a62019-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/607https://doaj.org/toc/2160-9381 Background: Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 integrin. Current literature has shown that a minority of patients present circulating antibodies to laminin-332 and this population seems to be associated with a relatively high risk of malignancy. Objective: To present our personal case series of patients with MMP-associated malignancy from a dermatology university hospital. Methods: Twenty-two patients affected by MMP were seen in the period between 2001 and 2016; in 4 patients (18%) an associated cancer was detected. Results: These patients were 2 men and 2 women, with a mean age of 69.7 years (range, 48-83). The associated malignancies included a breast cancer, a pancreatic adenocarcinoma, a metastatic laryngeal carcinoma, and a hepatic carcinoma. All patients had negative results for both BP180 and laminin-332 autoantibodies. Conclusion: We confirm that MMP patients have a relatively high possibility of developing a solid cancer, but the autoantibody detection is not mandatory and is probably correlated with the severity of the disease. Michelangelo La PlacaRiccardo BalestriFederico TartariAndrea SechiFrancesca FerraraCamilla LoiAnnalisa PatriziFederico BardazziMattioli1885articlemucous membrane pemphigoidmalignancyautoimmune bullous disordersparaneoplastic pemphiguslaminin-332blistering diseasesDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	mucous membrane pemphigoid malignancy autoimmune bullous disorders paraneoplastic pemphigus laminin-332 blistering diseases Dermatology RL1-803
spellingShingle	mucous membrane pemphigoid malignancy autoimmune bullous disorders paraneoplastic pemphigus laminin-332 blistering diseases Dermatology RL1-803 Michelangelo La Placa Riccardo Balestri Federico Tartari Andrea Sechi Francesca Ferrara Camilla Loi Annalisa Patrizi Federico Bardazzi Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature
description	Background: Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 integrin. Current literature has shown that a minority of patients present circulating antibodies to laminin-332 and this population seems to be associated with a relatively high risk of malignancy. Objective: To present our personal case series of patients with MMP-associated malignancy from a dermatology university hospital. Methods: Twenty-two patients affected by MMP were seen in the period between 2001 and 2016; in 4 patients (18%) an associated cancer was detected. Results: These patients were 2 men and 2 women, with a mean age of 69.7 years (range, 48-83). The associated malignancies included a breast cancer, a pancreatic adenocarcinoma, a metastatic laryngeal carcinoma, and a hepatic carcinoma. All patients had negative results for both BP180 and laminin-332 autoantibodies. Conclusion: We confirm that MMP patients have a relatively high possibility of developing a solid cancer, but the autoantibody detection is not mandatory and is probably correlated with the severity of the disease.
format	article
author	Michelangelo La Placa Riccardo Balestri Federico Tartari Andrea Sechi Francesca Ferrara Camilla Loi Annalisa Patrizi Federico Bardazzi
author_facet	Michelangelo La Placa Riccardo Balestri Federico Tartari Andrea Sechi Francesca Ferrara Camilla Loi Annalisa Patrizi Federico Bardazzi
author_sort	Michelangelo La Placa
title	Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature
title_short	Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature
title_full	Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature
title_fullStr	Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature
title_full_unstemmed	Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature
title_sort	mucous membrane pemphigoid-associated malignancies. case series and a brief overview of the literature
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/474f09521900426fa62198dbd21969a6
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Mucous Membrane Pemphigoid-Associated Malignancies. Case Series and a Brief Overview of the Literature

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