New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice

A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. Y. Rybalkina, N. N. Ermakova, T. G. Razina, E. G. Skurikhin, E. P. Zueva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	experimental model cyclophosphamide lewis lung carcinoma leukopenia Science Q
Acceso en línea:	https://doaj.org/article/47512e2174f547a4941b5e2961d55fea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:47512e2174f547a4941b5e2961d55fea
record_format	dspace
spelling	oai:doaj.org-article:47512e2174f547a4941b5e2961d55fea2021-11-23T06:14:36ZNew biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice2541-94202587-959610.12737/23406https://doaj.org/article/47512e2174f547a4941b5e2961d55fea2016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/292https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclophosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34 % on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7 times (p < 0,01). Metastatic area reduced. Metastasis frequency made 100 %. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia.O. Y. RybalkinaN. N. ErmakovaT. G. RazinaE. G. SkurikhinE. P. ZuevaScientific Сentre for Family Health and Human Reproduction Problemsarticleexperimental modelcyclophosphamidelewis lung carcinomaleukopeniaScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 121-125 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	experimental model cyclophosphamide lewis lung carcinoma leukopenia Science Q
spellingShingle	experimental model cyclophosphamide lewis lung carcinoma leukopenia Science Q O. Y. Rybalkina N. N. Ermakova T. G. Razina E. G. Skurikhin E. P. Zueva New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
description	A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclophosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34 % on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7 times (p < 0,01). Metastatic area reduced. Metastasis frequency made 100 %. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia.
format	article
author	O. Y. Rybalkina N. N. Ermakova T. G. Razina E. G. Skurikhin E. P. Zueva
author_facet	O. Y. Rybalkina N. N. Ermakova T. G. Razina E. G. Skurikhin E. P. Zueva
author_sort	O. Y. Rybalkina
title	New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
title_short	New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
title_full	New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
title_fullStr	New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
title_full_unstemmed	New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
title_sort	new biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/47512e2174f547a4941b5e2961d55fea
work_keys_str_mv	AT oyrybalkina newbiologicalmodelofmoderateinhibitionoftumorandmetastasesgrowthwithprolongedleukopeniainmice AT nnermakova newbiologicalmodelofmoderateinhibitionoftumorandmetastasesgrowthwithprolongedleukopeniainmice AT tgrazina newbiologicalmodelofmoderateinhibitionoftumorandmetastasesgrowthwithprolongedleukopeniainmice AT egskurikhin newbiologicalmodelofmoderateinhibitionoftumorandmetastasesgrowthwithprolongedleukopeniainmice AT epzueva newbiologicalmodelofmoderateinhibitionoftumorandmetastasesgrowthwithprolongedleukopeniainmice
_version_	1718417003373395968

New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice

Ejemplares similares