More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis

Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome system (UPS) to human diseases, and an array of proteasome inhibitors have been successfully developed for cancer therapy. Al...

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Autores principales:	Chengjun Cao, Chaoyang Xue
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ubiquitin-proteasome system (UPS) ubiquitin fungal pathogens E3 ligase drug discovery Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4751434feff54810ae49f05c80c947ad
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id	oai:doaj.org-article:4751434feff54810ae49f05c80c947ad
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spelling	oai:doaj.org-article:4751434feff54810ae49f05c80c947ad2021-11-10T05:58:35ZMore Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis2235-298810.3389/fcimb.2021.774613https://doaj.org/article/4751434feff54810ae49f05c80c947ad2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.774613/fullhttps://doaj.org/toc/2235-2988Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome system (UPS) to human diseases, and an array of proteasome inhibitors have been successfully developed for cancer therapy. Although still an emerging field, research on UPS regulation of fungal development and virulence has been rapidly advancing and has generated considerable excitement in its potential as a target for novel drugs. In this review, we summarize UPS composition and regulatory function in pathogenic fungi, especially in stress responses, host adaption, and fungal pathogenesis. Emphasis will be given to UPS regulation of pathogenic factors that are important for fungal pathogenesis. We also discuss future potential therapeutic strategies for fungal infections based on targeting UPS pathways.Chengjun CaoChaoyang XueChaoyang XueChaoyang XueFrontiers Media S.A.articleubiquitin-proteasome system (UPS)ubiquitinfungal pathogensE3 ligasedrug discoveryMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ubiquitin-proteasome system (UPS) ubiquitin fungal pathogens E3 ligase drug discovery Microbiology QR1-502
spellingShingle	ubiquitin-proteasome system (UPS) ubiquitin fungal pathogens E3 ligase drug discovery Microbiology QR1-502 Chengjun Cao Chaoyang Xue Chaoyang Xue Chaoyang Xue More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
description	Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome system (UPS) to human diseases, and an array of proteasome inhibitors have been successfully developed for cancer therapy. Although still an emerging field, research on UPS regulation of fungal development and virulence has been rapidly advancing and has generated considerable excitement in its potential as a target for novel drugs. In this review, we summarize UPS composition and regulatory function in pathogenic fungi, especially in stress responses, host adaption, and fungal pathogenesis. Emphasis will be given to UPS regulation of pathogenic factors that are important for fungal pathogenesis. We also discuss future potential therapeutic strategies for fungal infections based on targeting UPS pathways.
format	article
author	Chengjun Cao Chaoyang Xue Chaoyang Xue Chaoyang Xue
author_facet	Chengjun Cao Chaoyang Xue Chaoyang Xue Chaoyang Xue
author_sort	Chengjun Cao
title	More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
title_short	More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
title_full	More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
title_fullStr	More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
title_full_unstemmed	More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
title_sort	more than just cleaning: ubiquitin-mediated proteolysis in fungal pathogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4751434feff54810ae49f05c80c947ad
work_keys_str_mv	AT chengjuncao morethanjustcleaningubiquitinmediatedproteolysisinfungalpathogenesis AT chaoyangxue morethanjustcleaningubiquitinmediatedproteolysisinfungalpathogenesis AT chaoyangxue morethanjustcleaningubiquitinmediatedproteolysisinfungalpathogenesis AT chaoyangxue morethanjustcleaningubiquitinmediatedproteolysisinfungalpathogenesis
_version_	1718440464935288832

More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis

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