Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Our understanding of the genetics and treatment options for primary effusion lymphoma (PEL) is lacking. Here the authors performed in vitro CRISPR/Cas9 knock-out screens to identify 210 PEL-specific oncogenic genes and report strategies for therapeutic intervention.

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Autores principales:	Mark Manzano, Ajinkya Patil, Alexander Waldrop, Sandeep S. Dave, Amir Behdad, Eva Gottwein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4753b6af0a0c4636a623f9ba180cea46
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spelling	oai:doaj.org-article:4753b6af0a0c4636a623f9ba180cea462021-12-02T16:49:53ZGene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma10.1038/s41467-018-05506-92041-1723https://doaj.org/article/4753b6af0a0c4636a623f9ba180cea462018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05506-9https://doaj.org/toc/2041-1723Our understanding of the genetics and treatment options for primary effusion lymphoma (PEL) is lacking. Here the authors performed in vitro CRISPR/Cas9 knock-out screens to identify 210 PEL-specific oncogenic genes and report strategies for therapeutic intervention.Mark ManzanoAjinkya PatilAlexander WaldropSandeep S. DaveAmir BehdadEva GottweinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mark Manzano Ajinkya Patil Alexander Waldrop Sandeep S. Dave Amir Behdad Eva Gottwein Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
description	Our understanding of the genetics and treatment options for primary effusion lymphoma (PEL) is lacking. Here the authors performed in vitro CRISPR/Cas9 knock-out screens to identify 210 PEL-specific oncogenic genes and report strategies for therapeutic intervention.
format	article
author	Mark Manzano Ajinkya Patil Alexander Waldrop Sandeep S. Dave Amir Behdad Eva Gottwein
author_facet	Mark Manzano Ajinkya Patil Alexander Waldrop Sandeep S. Dave Amir Behdad Eva Gottwein
author_sort	Mark Manzano
title	Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
title_short	Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
title_full	Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
title_fullStr	Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
title_full_unstemmed	Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
title_sort	gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4753b6af0a0c4636a623f9ba180cea46
work_keys_str_mv	AT markmanzano geneessentialitylandscapeanddruggableoncogenicdependenciesinherpesviralprimaryeffusionlymphoma AT ajinkyapatil geneessentialitylandscapeanddruggableoncogenicdependenciesinherpesviralprimaryeffusionlymphoma AT alexanderwaldrop geneessentialitylandscapeanddruggableoncogenicdependenciesinherpesviralprimaryeffusionlymphoma AT sandeepsdave geneessentialitylandscapeanddruggableoncogenicdependenciesinherpesviralprimaryeffusionlymphoma AT amirbehdad geneessentialitylandscapeanddruggableoncogenicdependenciesinherpesviralprimaryeffusionlymphoma AT evagottwein geneessentialitylandscapeanddruggableoncogenicdependenciesinherpesviralprimaryeffusionlymphoma
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Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

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