Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Our understanding of the genetics and treatment options for primary effusion lymphoma (PEL) is lacking. Here the authors performed in vitro CRISPR/Cas9 knock-out screens to identify 210 PEL-specific oncogenic genes and report strategies for therapeutic intervention.

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Autores principales: Mark Manzano, Ajinkya Patil, Alexander Waldrop, Sandeep S. Dave, Amir Behdad, Eva Gottwein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/4753b6af0a0c4636a623f9ba180cea46
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