Therapeutic potential of omega fatty acids in breast cancer. Review

Background: Breast cancer is the second cause of death in women in developed and undeveloped countries, including Colombia. A high percentage of these tumors is estrogen dependent, for which the hormonal treatment is the most used therapy in breast cancer. Currently, the first line treatment for br...

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Autores principales:	María E. MÁRQUEZ-FERNÁNDEZ, Mauricio CAMARGO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2019
Materias:	Unsaturated fatty acids hormonal treatment fish oils anti-inflammatory agents. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/475503b7c30444209f9eefcf52a6c167
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spelling	oai:doaj.org-article:475503b7c30444209f9eefcf52a6c1672021-12-02T18:20:51ZTherapeutic potential of omega fatty acids in breast cancer. Review10.17533/udea.vitae.v26n1a040121-40042145-2660https://doaj.org/article/475503b7c30444209f9eefcf52a6c1672019-04-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/336337https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: Breast cancer is the second cause of death in women in developed and undeveloped countries, including Colombia. A high percentage of these tumors is estrogen dependent, for which the hormonal treatment is the most used therapy in breast cancer. Currently, the first line treatment for breast tumor in postmenopausal women is the letrozole, an aromatase enzyme inhibitor that avoids the transformation of androgens to estrogens. Since letrozole produced adverse effects on patients, there is a requirement for new alternative treatments. Furthermore, omega fatty acids (ω-FA), essential as they are obtained from the normal diet or from dietary supplements, have demonstrated nutraceutical potential because of their anti-inflammatory or pro-inflammatory activity. Nonetheless, there is controversy in in vitro, in vivo and epidemiologic reports regarding their preventive or inducing activities of carcinogenesis in animals and humans, depending on the structure of the ω-FA. Objectives: This review aims to show the main in vitro, in vivo and epidemiologic evidences of the chemotherapeutic potential of ω-3 and ω-6 FA in different types of neoplasm, particularly in breast cancer, in individual or combined treatments with diverse antineoplastics. Methods: PubMed and Science Direct databases revealed the most representative studies, published during the last two decades, about ω-3 and ω-6 FA, breast cancer and the principal therapeutic strategies for this neoplasm. Findings were presented in separated topics to provide an overview of ω-FA and their potential in treatments for breast cancer. Results: Patients treated with estrogens and progesterone derivate have shown predisposition to develop breast cancer after two years of continued therapy. Furthermore, ω-FA with known nutraceutical potential have demonstrated their potential as adjuvants in the treatment against different neoplasms, like hepatic and colon cancer. Conclusions: Current therapies for breast cancer and their low efficacy in the long term led to explore new alternative treatments with ω-FA. These essential fatty acids in daily consumption could enhance the antineoplastic agent effect. Nevertheless, metabolism of the ω-FA must be considered for this use. María E. MÁRQUEZ-FERNÁNDEZMauricio CAMARGOUniversidad de AntioquiaarticleUnsaturated fatty acidshormonal treatmentfish oilsanti-inflammatory agents.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 26, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Unsaturated fatty acids hormonal treatment fish oils anti-inflammatory agents. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Unsaturated fatty acids hormonal treatment fish oils anti-inflammatory agents. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 María E. MÁRQUEZ-FERNÁNDEZ Mauricio CAMARGO Therapeutic potential of omega fatty acids in breast cancer. Review
description	Background: Breast cancer is the second cause of death in women in developed and undeveloped countries, including Colombia. A high percentage of these tumors is estrogen dependent, for which the hormonal treatment is the most used therapy in breast cancer. Currently, the first line treatment for breast tumor in postmenopausal women is the letrozole, an aromatase enzyme inhibitor that avoids the transformation of androgens to estrogens. Since letrozole produced adverse effects on patients, there is a requirement for new alternative treatments. Furthermore, omega fatty acids (ω-FA), essential as they are obtained from the normal diet or from dietary supplements, have demonstrated nutraceutical potential because of their anti-inflammatory or pro-inflammatory activity. Nonetheless, there is controversy in in vitro, in vivo and epidemiologic reports regarding their preventive or inducing activities of carcinogenesis in animals and humans, depending on the structure of the ω-FA. Objectives: This review aims to show the main in vitro, in vivo and epidemiologic evidences of the chemotherapeutic potential of ω-3 and ω-6 FA in different types of neoplasm, particularly in breast cancer, in individual or combined treatments with diverse antineoplastics. Methods: PubMed and Science Direct databases revealed the most representative studies, published during the last two decades, about ω-3 and ω-6 FA, breast cancer and the principal therapeutic strategies for this neoplasm. Findings were presented in separated topics to provide an overview of ω-FA and their potential in treatments for breast cancer. Results: Patients treated with estrogens and progesterone derivate have shown predisposition to develop breast cancer after two years of continued therapy. Furthermore, ω-FA with known nutraceutical potential have demonstrated their potential as adjuvants in the treatment against different neoplasms, like hepatic and colon cancer. Conclusions: Current therapies for breast cancer and their low efficacy in the long term led to explore new alternative treatments with ω-FA. These essential fatty acids in daily consumption could enhance the antineoplastic agent effect. Nevertheless, metabolism of the ω-FA must be considered for this use.
format	article
author	María E. MÁRQUEZ-FERNÁNDEZ Mauricio CAMARGO
author_facet	María E. MÁRQUEZ-FERNÁNDEZ Mauricio CAMARGO
author_sort	María E. MÁRQUEZ-FERNÁNDEZ
title	Therapeutic potential of omega fatty acids in breast cancer. Review
title_short	Therapeutic potential of omega fatty acids in breast cancer. Review
title_full	Therapeutic potential of omega fatty acids in breast cancer. Review
title_fullStr	Therapeutic potential of omega fatty acids in breast cancer. Review
title_full_unstemmed	Therapeutic potential of omega fatty acids in breast cancer. Review
title_sort	therapeutic potential of omega fatty acids in breast cancer. review
publisher	Universidad de Antioquia
publishDate	2019
url	https://doaj.org/article/475503b7c30444209f9eefcf52a6c167
work_keys_str_mv	AT mariaemarquezfernandez therapeuticpotentialofomegafattyacidsinbreastcancerreview AT mauriciocamargo therapeuticpotentialofomegafattyacidsinbreastcancerreview
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Therapeutic potential of omega fatty acids in breast cancer. Review

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