Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders

Abstract Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Brice Martin, Nicolas Franck, Michel Cermolacce, Agnès Falco, Anabel Benair, Estelle Etienne, Sébastien Weibel, Jennifer T. Coull, Anne Giersch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4755f56125504a8e82bd1238be1088ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4755f56125504a8e82bd1238be1088ca
record_format	dspace
spelling	oai:doaj.org-article:4755f56125504a8e82bd1238be1088ca2021-12-02T15:04:52ZFragile temporal prediction in patients with schizophrenia is related to minimal self disorders10.1038/s41598-017-07987-y2045-2322https://doaj.org/article/4755f56125504a8e82bd1238be1088ca2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07987-yhttps://doaj.org/toc/2045-2322Abstract Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time (“hazard function”). This RT benefit was correlated with scores on the EASE scale, which measures disorders of the self: patients with a high ‘self-awareness and presence’ score did not show any significant benefit of the hazard function, whereas this ability was preserved in patients with a low score. Moreover, all patients were abnormally sensitive to the presence of “catch” trials (unexpected absence of a target) within a testing block, with RTs actually becoming slower at long versus short intervals. These results indicate fragility in patients’ ability to continuously extract temporally predictive information from the elapsing interval. This deficit might contribute to perturbations of the minimal self in patients.Brice MartinNicolas FranckMichel CermolacceAgnès FalcoAnabel BenairEstelle EtienneSébastien WeibelJennifer T. CoullAnne GierschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brice Martin Nicolas Franck Michel Cermolacce Agnès Falco Anabel Benair Estelle Etienne Sébastien Weibel Jennifer T. Coull Anne Giersch Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
description	Abstract Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time (“hazard function”). This RT benefit was correlated with scores on the EASE scale, which measures disorders of the self: patients with a high ‘self-awareness and presence’ score did not show any significant benefit of the hazard function, whereas this ability was preserved in patients with a low score. Moreover, all patients were abnormally sensitive to the presence of “catch” trials (unexpected absence of a target) within a testing block, with RTs actually becoming slower at long versus short intervals. These results indicate fragility in patients’ ability to continuously extract temporally predictive information from the elapsing interval. This deficit might contribute to perturbations of the minimal self in patients.
format	article
author	Brice Martin Nicolas Franck Michel Cermolacce Agnès Falco Anabel Benair Estelle Etienne Sébastien Weibel Jennifer T. Coull Anne Giersch
author_facet	Brice Martin Nicolas Franck Michel Cermolacce Agnès Falco Anabel Benair Estelle Etienne Sébastien Weibel Jennifer T. Coull Anne Giersch
author_sort	Brice Martin
title	Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
title_short	Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
title_full	Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
title_fullStr	Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
title_full_unstemmed	Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
title_sort	fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4755f56125504a8e82bd1238be1088ca
work_keys_str_mv	AT bricemartin fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT nicolasfranck fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT michelcermolacce fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT agnesfalco fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT anabelbenair fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT estelleetienne fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT sebastienweibel fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT jennifertcoull fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders AT annegiersch fragiletemporalpredictioninpatientswithschizophreniaisrelatedtominimalselfdisorders
_version_	1718389012927873024

Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders

Ejemplares similares