Genes and pathways associated with pregnancy loss in dairy cattle

Abstract Pregnancy loss directly impairs reproductive performance in dairy cattle. Here, we investigated genetic factors associated with pregnancy loss following detection of a viable embryo around 42 days of gestation. The objectives of this study were to perform whole-genome scans and subsequent g...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anil Sigdel, Rafael S. Bisinotto, Francisco Peñagaricano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4759892c5d264c1588442fe09bfaa00e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4759892c5d264c1588442fe09bfaa00e
record_format	dspace
spelling	oai:doaj.org-article:4759892c5d264c1588442fe09bfaa00e2021-12-02T16:07:03ZGenes and pathways associated with pregnancy loss in dairy cattle10.1038/s41598-021-92525-02045-2322https://doaj.org/article/4759892c5d264c1588442fe09bfaa00e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92525-0https://doaj.org/toc/2045-2322Abstract Pregnancy loss directly impairs reproductive performance in dairy cattle. Here, we investigated genetic factors associated with pregnancy loss following detection of a viable embryo around 42 days of gestation. The objectives of this study were to perform whole-genome scans and subsequent gene-set analyses for identifying candidate genes, functional gene-sets and gene signaling pathways implicated in pregnancy loss in US Holstein cows. Data consisted of about 58,000 pregnancy/abortion records distributed over nulliparous, primiparous, and multiparous cows. Threshold models were used to assess the binary response of pregnancy loss. Whole‐genome scans identified at least seven genomic regions on BTA2, BTA10, BTA14, BTA16, BTA21, BTA24 and BTA29 associated with pregnancy loss in heifers and lactating cows. These regions harbor several candidate genes that are directly implicated in pregnancy maintenance and fetal growth, such as CHST14, IGF1R, IGF2, PSEN2, SLC2A5 and WNT4. Moreover, the enrichment analysis revealed at least seven significantly enriched processes, containing genes associated with pregnancy loss, including calcium signaling, cell–cell attachment, cellular proliferation, fetal development, immunity, membrane permeability, and steroid metabolism. Additionally, the pathway analysis revealed a number of significant gene signaling pathways that regulate placental development and fetal growth, including Wnt, Hedgehog, Notch, MAPK, Hippo, mTOR and TGFβ pathways. Overall, our findings contribute to a better understanding of the genetic and biological basis of pregnancy loss in dairy cattle and points out novel strategies for improving pregnancy maintenance via marker‐assisted breeding.Anil SigdelRafael S. BisinottoFrancisco PeñagaricanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anil Sigdel Rafael S. Bisinotto Francisco Peñagaricano Genes and pathways associated with pregnancy loss in dairy cattle
description	Abstract Pregnancy loss directly impairs reproductive performance in dairy cattle. Here, we investigated genetic factors associated with pregnancy loss following detection of a viable embryo around 42 days of gestation. The objectives of this study were to perform whole-genome scans and subsequent gene-set analyses for identifying candidate genes, functional gene-sets and gene signaling pathways implicated in pregnancy loss in US Holstein cows. Data consisted of about 58,000 pregnancy/abortion records distributed over nulliparous, primiparous, and multiparous cows. Threshold models were used to assess the binary response of pregnancy loss. Whole‐genome scans identified at least seven genomic regions on BTA2, BTA10, BTA14, BTA16, BTA21, BTA24 and BTA29 associated with pregnancy loss in heifers and lactating cows. These regions harbor several candidate genes that are directly implicated in pregnancy maintenance and fetal growth, such as CHST14, IGF1R, IGF2, PSEN2, SLC2A5 and WNT4. Moreover, the enrichment analysis revealed at least seven significantly enriched processes, containing genes associated with pregnancy loss, including calcium signaling, cell–cell attachment, cellular proliferation, fetal development, immunity, membrane permeability, and steroid metabolism. Additionally, the pathway analysis revealed a number of significant gene signaling pathways that regulate placental development and fetal growth, including Wnt, Hedgehog, Notch, MAPK, Hippo, mTOR and TGFβ pathways. Overall, our findings contribute to a better understanding of the genetic and biological basis of pregnancy loss in dairy cattle and points out novel strategies for improving pregnancy maintenance via marker‐assisted breeding.
format	article
author	Anil Sigdel Rafael S. Bisinotto Francisco Peñagaricano
author_facet	Anil Sigdel Rafael S. Bisinotto Francisco Peñagaricano
author_sort	Anil Sigdel
title	Genes and pathways associated with pregnancy loss in dairy cattle
title_short	Genes and pathways associated with pregnancy loss in dairy cattle
title_full	Genes and pathways associated with pregnancy loss in dairy cattle
title_fullStr	Genes and pathways associated with pregnancy loss in dairy cattle
title_full_unstemmed	Genes and pathways associated with pregnancy loss in dairy cattle
title_sort	genes and pathways associated with pregnancy loss in dairy cattle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4759892c5d264c1588442fe09bfaa00e
work_keys_str_mv	AT anilsigdel genesandpathwaysassociatedwithpregnancylossindairycattle AT rafaelsbisinotto genesandpathwaysassociatedwithpregnancylossindairycattle AT franciscopenagaricano genesandpathwaysassociatedwithpregnancylossindairycattle
_version_	1718384772255842304

Genes and pathways associated with pregnancy loss in dairy cattle

Ejemplares similares