Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems

The next-generation sequencing detecting gene mutation has been recommended for the routine diagnosis of suspicious myelodysplastic symdromes patients. Recently, several pre-MDS conditions, a new subtype MDS with SF3B1, gene mutations integrated prognosis scores and gene mutations-based clinical dec...

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Autor principal:	XIAO Zhijian
Formato:	article
Lenguaje:	ZH
Publicado:	Magazine House of Cancer Research on Prevention and Treatment 2021
Materias:	next-generation sequencing myelodysplastic syndromes gene mutations Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/47599705a27248dcab6d98d057123448
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spelling	oai:doaj.org-article:47599705a27248dcab6d98d0571234482021-12-03T09:25:17ZApplication of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems1000-857810.3971/j.issn.1000-8578.2021.21.0921https://doaj.org/article/47599705a27248dcab6d98d0571234482021-11-01T00:00:00Zhttp://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.21.0921https://doaj.org/toc/1000-8578The next-generation sequencing detecting gene mutation has been recommended for the routine diagnosis of suspicious myelodysplastic symdromes patients. Recently, several pre-MDS conditions, a new subtype MDS with SF3B1, gene mutations integrated prognosis scores and gene mutations-based clinical decision-making and treatment choice were proposed. Nowadays, it is a big problem to standardize the generation, analysis, clinical interpretation and reporting of NGS data in China. It will open new horizons for individualized medicine of patients with MDS in the future by implementing integrated genomics into the diagnostic and treatment algorithms.XIAO ZhijianMagazine House of Cancer Research on Prevention and Treatmentarticlenext-generation sequencingmyelodysplastic syndromesgene mutationsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ZHZhongliu Fangzhi Yanjiu, Vol 48, Iss 11, Pp 985-988 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	next-generation sequencing myelodysplastic syndromes gene mutations Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	next-generation sequencing myelodysplastic syndromes gene mutations Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 XIAO Zhijian Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems
description	The next-generation sequencing detecting gene mutation has been recommended for the routine diagnosis of suspicious myelodysplastic symdromes patients. Recently, several pre-MDS conditions, a new subtype MDS with SF3B1, gene mutations integrated prognosis scores and gene mutations-based clinical decision-making and treatment choice were proposed. Nowadays, it is a big problem to standardize the generation, analysis, clinical interpretation and reporting of NGS data in China. It will open new horizons for individualized medicine of patients with MDS in the future by implementing integrated genomics into the diagnostic and treatment algorithms.
format	article
author	XIAO Zhijian
author_facet	XIAO Zhijian
author_sort	XIAO Zhijian
title	Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems
title_short	Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems
title_full	Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems
title_fullStr	Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems
title_full_unstemmed	Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems
title_sort	application of next-generation sequencing detecting gene mutation in myelodysplastic syndromes: current situation and problems
publisher	Magazine House of Cancer Research on Prevention and Treatment
publishDate	2021
url	https://doaj.org/article/47599705a27248dcab6d98d057123448
work_keys_str_mv	AT xiaozhijian applicationofnextgenerationsequencingdetectinggenemutationinmyelodysplasticsyndromescurrentsituationandproblems
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Application of Next-generation Sequencing Detecting Gene Mutation in Myelodysplastic Syndromes: Current Situation and Problems

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