OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human

Although the interactors of pluripotency factors have been identified in mouse embryonic stem cells (ESCs), their interactors in human ESCs remain unexplored. Here the authors map OCT4 protein interactions in naïve and primed human ESCs to find specific interactions with BAF subunits that promote an...

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Autores principales:	Xin Huang, Kyoung-mi Park, Paul Gontarz, Bo Zhang, Joshua Pan, Zachary McKenzie, Laura A. Fischer, Chen Dong, Sabine Dietmann, Xiaoyun Xing, Pavel V. Shliaha, Jihong Yang, Dan Li, Junjun Ding, Tenzin Lungjangwa, Maya Mitalipova, Shafqat A. Khan, Sumeth Imsoonthornruksa, Nick Jensen, Ting Wang, Cigall Kadoch, Rudolf Jaenisch, Jianlong Wang, Thorold W. Theunissen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/475ca4c998cb484bb6963209f6ebdc13
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spelling	oai:doaj.org-article:475ca4c998cb484bb6963209f6ebdc132021-12-02T19:02:35ZOCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human10.1038/s41467-021-25107-32041-1723https://doaj.org/article/475ca4c998cb484bb6963209f6ebdc132021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25107-3https://doaj.org/toc/2041-1723Although the interactors of pluripotency factors have been identified in mouse embryonic stem cells (ESCs), their interactors in human ESCs remain unexplored. Here the authors map OCT4 protein interactions in naïve and primed human ESCs to find specific interactions with BAF subunits that promote an open chromatin architecture at blastocyst-associated genes and ectodermal genes, respectively.Xin HuangKyoung-mi ParkPaul GontarzBo ZhangJoshua PanZachary McKenzieLaura A. FischerChen DongSabine DietmannXiaoyun XingPavel V. ShliahaJihong YangDan LiJunjun DingTenzin LungjangwaMaya MitalipovaShafqat A. KhanSumeth ImsoonthornruksaNick JensenTing WangCigall KadochRudolf JaenischJianlong WangThorold W. TheunissenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Huang Kyoung-mi Park Paul Gontarz Bo Zhang Joshua Pan Zachary McKenzie Laura A. Fischer Chen Dong Sabine Dietmann Xiaoyun Xing Pavel V. Shliaha Jihong Yang Dan Li Junjun Ding Tenzin Lungjangwa Maya Mitalipova Shafqat A. Khan Sumeth Imsoonthornruksa Nick Jensen Ting Wang Cigall Kadoch Rudolf Jaenisch Jianlong Wang Thorold W. Theunissen OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
description	Although the interactors of pluripotency factors have been identified in mouse embryonic stem cells (ESCs), their interactors in human ESCs remain unexplored. Here the authors map OCT4 protein interactions in naïve and primed human ESCs to find specific interactions with BAF subunits that promote an open chromatin architecture at blastocyst-associated genes and ectodermal genes, respectively.
format	article
author	Xin Huang Kyoung-mi Park Paul Gontarz Bo Zhang Joshua Pan Zachary McKenzie Laura A. Fischer Chen Dong Sabine Dietmann Xiaoyun Xing Pavel V. Shliaha Jihong Yang Dan Li Junjun Ding Tenzin Lungjangwa Maya Mitalipova Shafqat A. Khan Sumeth Imsoonthornruksa Nick Jensen Ting Wang Cigall Kadoch Rudolf Jaenisch Jianlong Wang Thorold W. Theunissen
author_facet	Xin Huang Kyoung-mi Park Paul Gontarz Bo Zhang Joshua Pan Zachary McKenzie Laura A. Fischer Chen Dong Sabine Dietmann Xiaoyun Xing Pavel V. Shliaha Jihong Yang Dan Li Junjun Ding Tenzin Lungjangwa Maya Mitalipova Shafqat A. Khan Sumeth Imsoonthornruksa Nick Jensen Ting Wang Cigall Kadoch Rudolf Jaenisch Jianlong Wang Thorold W. Theunissen
author_sort	Xin Huang
title	OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
title_short	OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
title_full	OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
title_fullStr	OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
title_full_unstemmed	OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human
title_sort	oct4 cooperates with distinct atp-dependent chromatin remodelers in naïve and primed pluripotent states in human
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/475ca4c998cb484bb6963209f6ebdc13
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OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human

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