Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Abstract Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different...

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Autores principales:	Xueyi Shen, Lianne M. Reus, Simon R. Cox, Mark J. Adams, David C. Liewald, Mark E. Bastin, Daniel J. Smith, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/475d9a08c3a4447fa78915c961e9faf6
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spelling	oai:doaj.org-article:475d9a08c3a4447fa78915c961e9faf62021-12-02T11:53:08ZSubcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data10.1038/s41598-017-05507-62045-2322https://doaj.org/article/475d9a08c3a4447fa78915c961e9faf62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05507-6https://doaj.org/toc/2045-2322Abstract Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β = −0.182, p = 0.005). We also found reductions in FA in association/commissural fibres (β = −0.184, pcorrected = 0.010) and thalamic radiations (β = −0.159, pcorrected = 0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β = −0.194, pcorrected = 0.025), superior thalamic radiation (β = −0.224, pcorrected = 0.009) and forceps major (β = −0.193, pcorrected = 0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.Xueyi ShenLianne M. ReusSimon R. CoxMark J. AdamsDavid C. LiewaldMark E. BastinDaniel J. SmithIan J. DearyHeather C. WhalleyAndrew M. McIntoshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueyi Shen Lianne M. Reus Simon R. Cox Mark J. Adams David C. Liewald Mark E. Bastin Daniel J. Smith Ian J. Deary Heather C. Whalley Andrew M. McIntosh Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
description	Abstract Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β = −0.182, p = 0.005). We also found reductions in FA in association/commissural fibres (β = −0.184, pcorrected = 0.010) and thalamic radiations (β = −0.159, pcorrected = 0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β = −0.194, pcorrected = 0.025), superior thalamic radiation (β = −0.224, pcorrected = 0.009) and forceps major (β = −0.193, pcorrected = 0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.
format	article
author	Xueyi Shen Lianne M. Reus Simon R. Cox Mark J. Adams David C. Liewald Mark E. Bastin Daniel J. Smith Ian J. Deary Heather C. Whalley Andrew M. McIntosh
author_facet	Xueyi Shen Lianne M. Reus Simon R. Cox Mark J. Adams David C. Liewald Mark E. Bastin Daniel J. Smith Ian J. Deary Heather C. Whalley Andrew M. McIntosh
author_sort	Xueyi Shen
title	Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
title_short	Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
title_full	Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
title_fullStr	Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
title_full_unstemmed	Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
title_sort	subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from uk biobank imaging data
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/475d9a08c3a4447fa78915c961e9faf6
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_version_	1718394863352807424

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

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