Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis

Abstract Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care expenditure. Intestinal microbiota have variously been implicated as either contributing to gallstone formation or to be affected by cholecyste...

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Autores principales:	Fabian Frost, Tim Kacprowski, Malte Rühlemann, Stefan Weiss, Corinna Bang, Andre Franke, Maik Pietzner, Ali A. Aghdassi, Matthias Sendler, Uwe Völker, Henry Völzke, Julia Mayerle, Frank U. Weiss, Georg Homuth, Markus M. Lerch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/475fbfa266654d25ba6d1a4c3a5fb3e3
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spelling	oai:doaj.org-article:475fbfa266654d25ba6d1a4c3a5fb3e32021-12-02T14:02:55ZCarrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis10.1038/s41598-021-86247-62045-2322https://doaj.org/article/475fbfa266654d25ba6d1a4c3a5fb3e32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86247-6https://doaj.org/toc/2045-2322Abstract Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care expenditure. Intestinal microbiota have variously been implicated as either contributing to gallstone formation or to be affected by cholecystectomy. We conducted a large-scale investigation on 404 gallstone carriers, 580 individuals post-cholecystectomy and 984 healthy controls with similar distributions of age, sex, body mass index, smoking habits, and food-frequency-score. All 1968 subjects were recruited from the population-based Study-of-Health-in-Pomerania (SHIP), which includes transabdominal gallbladder ultrasound. Fecal microbiota profiles were determined by 16S rRNA gene sequencing. No significant differences in microbiota composition were detected between gallstone carriers and controls. Individuals post-cholecystectomy exhibited reduced microbiota diversity, a decrease in the potentially beneficial genus Faecalibacterium and an increase in the opportunistic pathogen Escherichia/Shigella. The absence of an association between the gut microbiota and the presence of gallbladder stones suggests that there is no intestinal microbial risk profile increasing the likelihood of gallstone formation. Cholecystectomy, on the other hand, is associated with distinct microbiota changes that have previously been implicated in unfavorable health effects and may not only contribute to gastrointestinal infection but also to the increased colon cancer risk of cholecystectomized patients.Fabian FrostTim KacprowskiMalte RühlemannStefan WeissCorinna BangAndre FrankeMaik PietznerAli A. AghdassiMatthias SendlerUwe VölkerHenry VölzkeJulia MayerleFrank U. WeissGeorg HomuthMarkus M. LerchNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabian Frost Tim Kacprowski Malte Rühlemann Stefan Weiss Corinna Bang Andre Franke Maik Pietzner Ali A. Aghdassi Matthias Sendler Uwe Völker Henry Völzke Julia Mayerle Frank U. Weiss Georg Homuth Markus M. Lerch Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
description	Abstract Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care expenditure. Intestinal microbiota have variously been implicated as either contributing to gallstone formation or to be affected by cholecystectomy. We conducted a large-scale investigation on 404 gallstone carriers, 580 individuals post-cholecystectomy and 984 healthy controls with similar distributions of age, sex, body mass index, smoking habits, and food-frequency-score. All 1968 subjects were recruited from the population-based Study-of-Health-in-Pomerania (SHIP), which includes transabdominal gallbladder ultrasound. Fecal microbiota profiles were determined by 16S rRNA gene sequencing. No significant differences in microbiota composition were detected between gallstone carriers and controls. Individuals post-cholecystectomy exhibited reduced microbiota diversity, a decrease in the potentially beneficial genus Faecalibacterium and an increase in the opportunistic pathogen Escherichia/Shigella. The absence of an association between the gut microbiota and the presence of gallbladder stones suggests that there is no intestinal microbial risk profile increasing the likelihood of gallstone formation. Cholecystectomy, on the other hand, is associated with distinct microbiota changes that have previously been implicated in unfavorable health effects and may not only contribute to gastrointestinal infection but also to the increased colon cancer risk of cholecystectomized patients.
format	article
author	Fabian Frost Tim Kacprowski Malte Rühlemann Stefan Weiss Corinna Bang Andre Franke Maik Pietzner Ali A. Aghdassi Matthias Sendler Uwe Völker Henry Völzke Julia Mayerle Frank U. Weiss Georg Homuth Markus M. Lerch
author_facet	Fabian Frost Tim Kacprowski Malte Rühlemann Stefan Weiss Corinna Bang Andre Franke Maik Pietzner Ali A. Aghdassi Matthias Sendler Uwe Völker Henry Völzke Julia Mayerle Frank U. Weiss Georg Homuth Markus M. Lerch
author_sort	Fabian Frost
title	Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
title_short	Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
title_full	Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
title_fullStr	Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
title_full_unstemmed	Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
title_sort	carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/475fbfa266654d25ba6d1a4c3a5fb3e3
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Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis

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