Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans

Shenghui Wu,1 Joseph B McCormick,2 Joanne E Curran,3 Susan P Fisher-Hoch2 1Department of Epidemiology and Biostatistics, University of Texas Health at San Antonio-Laredo Campus, Laredo, 2Division of Epidemiology, University of Texas Health Science Center-Houston, School of Public Health, Brownsville...

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Autores principales:	Wu SH, McCormick JB, Curran JE, Fisher-Hoch SP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Transition Pre-Diabetes Diabetes Predictors Risk Mexican-Americans Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4760892835b5431e94f5ccc75bc61f2a
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spelling	oai:doaj.org-article:4760892835b5431e94f5ccc75bc61f2a2021-12-02T04:25:54ZTransition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans1178-7007https://doaj.org/article/4760892835b5431e94f5ccc75bc61f2a2017-12-01T00:00:00Zhttps://www.dovepress.com/transition-from-pre-diabetes-to-diabetes-and-predictors-of-risk-in-mex-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shenghui Wu,1 Joseph B McCormick,2 Joanne E Curran,3 Susan P Fisher-Hoch2 1Department of Epidemiology and Biostatistics, University of Texas Health at San Antonio-Laredo Campus, Laredo, 2Division of Epidemiology, University of Texas Health Science Center-Houston, School of Public Health, Brownsville Campus, Brownsville, 3South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville Campus, Brownsville, TX, USA Background: No studies have examined risk factors for the transition from pre-diabetes to diabetes in populations with widespread obesity and diabetes. We determined proximal changes and factors affecting the transition among Mexican-Americans with pre-diabetes.Methods: Participants with pre-diabetes (n=285) were recruited from our randomly sampled population-based Cameron County Hispanic Cohort. These participants were followed for an average of 27 months with repeat examination every 3 to 4 months. Metabolic health was defined as having less than 2 metabolic abnormalities (e.g., hypertension, elevated low-density lipoprotein, etc). Diabetes was identified as fasting blood glucose ≥126 mg/dL, glycated hemoglobin ≥6.5% and/or on hypoglycemic medication.Results: Ninety-six of 285 (33.7%) participants transitioned to overt diabetes. The increased risk of diabetes in the metabolically unhealthy varying with follow-up time was 81% (adjusted odds ratio [OR]: 1.81; 95% CI: 1.09–3.02). The risk of diabetes increased 8% for each kg/m2 of increase in body mass index (BMI, OR: 1.08; 95% CI: 1.05–1.11) independent of covariates. Transition to diabetes was accompanied by a mean increase in BMI of 0.28 kg/m2, and deterioration in metabolic health of 9% (OR: 1.09; 95% CI: 1.003–1.18) compared with those who did not transition.Conclusions: Deteriorating metabolic health and/or increasing BMI significantly raises the risk of transitioning from pre-diabetes to diabetes. Transition itself was accompanied by further increase in BMI and deterioration in metabolic health. These data underline the importance of improving metabolic health and avoiding weight gain in pre-diabetes as simple but clear diabetes prevention targets, and emphasize the importance of lifestyle management. Keywords: transition, pre-diabetes, diabetes, predictors, risk, Mexican-Americans, Hispanic, Latino Wu SHMcCormick JBCurran JEFisher-Hoch SPDove Medical PressarticleTransitionPre-DiabetesDiabetesPredictorsRiskMexican-AmericansSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 491-503 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transition Pre-Diabetes Diabetes Predictors Risk Mexican-Americans Specialties of internal medicine RC581-951
spellingShingle	Transition Pre-Diabetes Diabetes Predictors Risk Mexican-Americans Specialties of internal medicine RC581-951 Wu SH McCormick JB Curran JE Fisher-Hoch SP Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans
description	Shenghui Wu,1 Joseph B McCormick,2 Joanne E Curran,3 Susan P Fisher-Hoch2 1Department of Epidemiology and Biostatistics, University of Texas Health at San Antonio-Laredo Campus, Laredo, 2Division of Epidemiology, University of Texas Health Science Center-Houston, School of Public Health, Brownsville Campus, Brownsville, 3South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville Campus, Brownsville, TX, USA Background: No studies have examined risk factors for the transition from pre-diabetes to diabetes in populations with widespread obesity and diabetes. We determined proximal changes and factors affecting the transition among Mexican-Americans with pre-diabetes.Methods: Participants with pre-diabetes (n=285) were recruited from our randomly sampled population-based Cameron County Hispanic Cohort. These participants were followed for an average of 27 months with repeat examination every 3 to 4 months. Metabolic health was defined as having less than 2 metabolic abnormalities (e.g., hypertension, elevated low-density lipoprotein, etc). Diabetes was identified as fasting blood glucose ≥126 mg/dL, glycated hemoglobin ≥6.5% and/or on hypoglycemic medication.Results: Ninety-six of 285 (33.7%) participants transitioned to overt diabetes. The increased risk of diabetes in the metabolically unhealthy varying with follow-up time was 81% (adjusted odds ratio [OR]: 1.81; 95% CI: 1.09–3.02). The risk of diabetes increased 8% for each kg/m2 of increase in body mass index (BMI, OR: 1.08; 95% CI: 1.05–1.11) independent of covariates. Transition to diabetes was accompanied by a mean increase in BMI of 0.28 kg/m2, and deterioration in metabolic health of 9% (OR: 1.09; 95% CI: 1.003–1.18) compared with those who did not transition.Conclusions: Deteriorating metabolic health and/or increasing BMI significantly raises the risk of transitioning from pre-diabetes to diabetes. Transition itself was accompanied by further increase in BMI and deterioration in metabolic health. These data underline the importance of improving metabolic health and avoiding weight gain in pre-diabetes as simple but clear diabetes prevention targets, and emphasize the importance of lifestyle management. Keywords: transition, pre-diabetes, diabetes, predictors, risk, Mexican-Americans, Hispanic, Latino
format	article
author	Wu SH McCormick JB Curran JE Fisher-Hoch SP
author_facet	Wu SH McCormick JB Curran JE Fisher-Hoch SP
author_sort	Wu SH
title	Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans
title_short	Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans
title_full	Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans
title_fullStr	Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans
title_full_unstemmed	Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans
title_sort	transition from pre-diabetes to diabetes and predictors of risk in mexican-americans
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4760892835b5431e94f5ccc75bc61f2a
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_version_	1718401181573709824

Transition from pre-diabetes to diabetes and predictors of risk in Mexican-Americans

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