Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorder...

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Autores principales:	Herbert Schulz, Ann-Kathrin Ruppert, Stefan Herms, Christiane Wolf, Nazanin Mirza-Schreiber, Oliver Stegle, Darina Czamara, Andreas J. Forstner, Sugirthan Sivalingam, Susanne Schoch, Susanne Moebus, Benno Pütz, Axel Hillmer, Nadine Fricker, Hartmut Vatter, Bertram Müller-Myhsok, Markus M. Nöthen, Albert J. Becker, Per Hoffmann, Thomas Sander, Sven Cichon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4760a9c2746b4a878c2dfd7b18475253
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spelling	oai:doaj.org-article:4760a9c2746b4a878c2dfd7b184752532021-12-02T17:06:21ZGenome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus10.1038/s41467-017-01818-42041-1723https://doaj.org/article/4760a9c2746b4a878c2dfd7b184752532017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01818-4https://doaj.org/toc/2041-1723Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorders.Herbert SchulzAnn-Kathrin RuppertStefan HermsChristiane WolfNazanin Mirza-SchreiberOliver StegleDarina CzamaraAndreas J. ForstnerSugirthan SivalingamSusanne SchochSusanne MoebusBenno PützAxel HillmerNadine FrickerHartmut VatterBertram Müller-MyhsokMarkus M. NöthenAlbert J. BeckerPer HoffmannThomas SanderSven CichonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Herbert Schulz Ann-Kathrin Ruppert Stefan Herms Christiane Wolf Nazanin Mirza-Schreiber Oliver Stegle Darina Czamara Andreas J. Forstner Sugirthan Sivalingam Susanne Schoch Susanne Moebus Benno Pütz Axel Hillmer Nadine Fricker Hartmut Vatter Bertram Müller-Myhsok Markus M. Nöthen Albert J. Becker Per Hoffmann Thomas Sander Sven Cichon Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
description	Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorders.
format	article
author	Herbert Schulz Ann-Kathrin Ruppert Stefan Herms Christiane Wolf Nazanin Mirza-Schreiber Oliver Stegle Darina Czamara Andreas J. Forstner Sugirthan Sivalingam Susanne Schoch Susanne Moebus Benno Pütz Axel Hillmer Nadine Fricker Hartmut Vatter Bertram Müller-Myhsok Markus M. Nöthen Albert J. Becker Per Hoffmann Thomas Sander Sven Cichon
author_facet	Herbert Schulz Ann-Kathrin Ruppert Stefan Herms Christiane Wolf Nazanin Mirza-Schreiber Oliver Stegle Darina Czamara Andreas J. Forstner Sugirthan Sivalingam Susanne Schoch Susanne Moebus Benno Pütz Axel Hillmer Nadine Fricker Hartmut Vatter Bertram Müller-Myhsok Markus M. Nöthen Albert J. Becker Per Hoffmann Thomas Sander Sven Cichon
author_sort	Herbert Schulz
title	Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
title_short	Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
title_full	Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
title_fullStr	Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
title_full_unstemmed	Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus
title_sort	genome-wide mapping of genetic determinants influencing dna methylation and gene expression in human hippocampus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4760a9c2746b4a878c2dfd7b18475253
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Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

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