B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes...

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Autores principales:	Yuwen Li, Xiaodan Ma, Zhiming Chen, Haiyan Wu, Pengran Wang, Wenyu Wu, Nuo Cheng, Longhui Zeng, Hao Zhang, Xun Cai, Sai-Juan Chen, Zhu Chen, Guoyu Meng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/476343b2924041758754a532fd02840f
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spelling	oai:doaj.org-article:476343b2924041758754a532fd02840f2021-12-02T17:02:03ZB1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis10.1038/s41467-019-11746-02041-1723https://doaj.org/article/476343b2924041758754a532fd02840f2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11746-0https://doaj.org/toc/2041-1723Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes promyelocytic leukemia leukemogenesis in transgenic mice.Yuwen LiXiaodan MaZhiming ChenHaiyan WuPengran WangWenyu WuNuo ChengLonghui ZengHao ZhangXun CaiSai-Juan ChenZhu ChenGuoyu MengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuwen Li Xiaodan Ma Zhiming Chen Haiyan Wu Pengran Wang Wenyu Wu Nuo Cheng Longhui Zeng Hao Zhang Xun Cai Sai-Juan Chen Zhu Chen Guoyu Meng B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
description	Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show that disrupting B1-B1 interactions precludes promyelocytic leukemia leukemogenesis in transgenic mice.
format	article
author	Yuwen Li Xiaodan Ma Zhiming Chen Haiyan Wu Pengran Wang Wenyu Wu Nuo Cheng Longhui Zeng Hao Zhang Xun Cai Sai-Juan Chen Zhu Chen Guoyu Meng
author_facet	Yuwen Li Xiaodan Ma Zhiming Chen Haiyan Wu Pengran Wang Wenyu Wu Nuo Cheng Longhui Zeng Hao Zhang Xun Cai Sai-Juan Chen Zhu Chen Guoyu Meng
author_sort	Yuwen Li
title	B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
title_short	B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
title_full	B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
title_fullStr	B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
title_full_unstemmed	B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
title_sort	b1 oligomerization regulates pml nuclear body biogenesis and leukemogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/476343b2924041758754a532fd02840f
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B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

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