Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4.

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Autores principales:	Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou, Jin-Tang Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4767d9e2f20b432ab88e90cb4777af44
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spelling	oai:doaj.org-article:4767d9e2f20b432ab88e90cb4777af442021-12-02T13:17:39ZAcetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer10.1038/s41467-021-21976-w2041-1723https://doaj.org/article/4767d9e2f20b432ab88e90cb4777af442021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21976-whttps://doaj.org/toc/2041-1723The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4.Baotong ZhangYixiang LiQiao WuLin XieBenjamin BarwickChangying FuXin LiDaqing WuSiyuan XiaJing ChenWei Ping QianLily YangAdeboye O. OsunkoyaLawrence BoisePaula M. VertinoYichao ZhaoMenglin LiHsiao-Rong ChenJeanne KowalskiOmer KucukWei ZhouJin-Tang DongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baotong Zhang Yixiang Li Qiao Wu Lin Xie Benjamin Barwick Changying Fu Xin Li Daqing Wu Siyuan Xia Jing Chen Wei Ping Qian Lily Yang Adeboye O. Osunkoya Lawrence Boise Paula M. Vertino Yichao Zhao Menglin Li Hsiao-Rong Chen Jeanne Kowalski Omer Kucuk Wei Zhou Jin-Tang Dong Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
description	The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and resistance to docetaxel by upregulating CXCR4.
format	article
author	Baotong Zhang Yixiang Li Qiao Wu Lin Xie Benjamin Barwick Changying Fu Xin Li Daqing Wu Siyuan Xia Jing Chen Wei Ping Qian Lily Yang Adeboye O. Osunkoya Lawrence Boise Paula M. Vertino Yichao Zhao Menglin Li Hsiao-Rong Chen Jeanne Kowalski Omer Kucuk Wei Zhou Jin-Tang Dong
author_facet	Baotong Zhang Yixiang Li Qiao Wu Lin Xie Benjamin Barwick Changying Fu Xin Li Daqing Wu Siyuan Xia Jing Chen Wei Ping Qian Lily Yang Adeboye O. Osunkoya Lawrence Boise Paula M. Vertino Yichao Zhao Menglin Li Hsiao-Rong Chen Jeanne Kowalski Omer Kucuk Wei Zhou Jin-Tang Dong
author_sort	Baotong Zhang
title	Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
title_short	Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
title_full	Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
title_fullStr	Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
title_full_unstemmed	Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
title_sort	acetylation of klf5 maintains emt and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4767d9e2f20b432ab88e90cb4777af44
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Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

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