Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy
Background: The association between inflammation and neurodegeneration has long been observed in parkinson’s disease (PD) and multiple system atrophy (MSA). Previous genome-wide association studies (GWAS) and meta-analyses have identified several risk loci in inflammation-associated genes associated...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:4769c9cc41c445d7bc226fded8a1cedf2021-11-18T05:51:59ZAssociation Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy1664-802110.3389/fgene.2021.765833https://doaj.org/article/4769c9cc41c445d7bc226fded8a1cedf2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.765833/fullhttps://doaj.org/toc/1664-8021Background: The association between inflammation and neurodegeneration has long been observed in parkinson’s disease (PD) and multiple system atrophy (MSA). Previous genome-wide association studies (GWAS) and meta-analyses have identified several risk loci in inflammation-associated genes associated with PD.Objective: To investigate whether polymorphisms in some inflammation-associated genes could modulate the risk of developing PD and MSA in a Southwest Chinese population.Methods: A total of 2,706 Chinese subjects comprising 1340 PD, 483 MSA and 883 healthy controls were recruited in the study. Three polymorphisms (rs2074404 GG/GT/TT, rs17425622 CC/CT/TT, rs34043159 CC/CT/TT) in genes linked to inflammation in all the subjects were genotyped by using the Sequenom iPLEX Assay.Results: The allele G of WNT3 rs2074404 can increase risk on PD (OR: 1.048, 95% CI: 1.182–1.333, p = 0.006), exclusively in the LOPD subgroup (OR: 1.166, 95% CI:1.025–1.327, p = 0.019), but not in EOPD or MSA. And the recessive model analysis also demonstrated an increased PD risk in GG genotype of this locus (OR = 1.331, p = 0.007). However, no significant differences were observed in the genotype distributions and alleles of HLA-DRB5 rs17425622 and IL1R2 rs34043159 between the PD patients and controls, between the MSA patients and controls, or between subgroups of PD or MSA and controls.Conclusion: Our results suggested the allele G of WNT3 rs2074404 have an adverse effect on PD and particularly, on the LOPD subgroup among a Chinese population.Wei-Ming SuWei-Ming SuWei-Ming SuXiao-Jing GuXiao-Jing GuXiao-Jing GuYan-Bing HouYan-Bing HouYan-Bing HouLing-Yu ZhangLing-Yu ZhangLing-Yu ZhangBei CaoBei CaoBei CaoRu-Wei OuRu-Wei OuRu-Wei OuYing WuYing WuYing WuXue-Ping ChenXue-Ping ChenXue-Ping ChenWei SongWei SongWei SongBi ZhaoBi ZhaoBi ZhaoHui-Fang ShangHui-Fang ShangHui-Fang ShangYong-Ping ChenYong-Ping ChenYong-Ping ChenFrontiers Media S.A.articleparkinsion’s diseasemultiple system atrophyWnt3HLA-DRB5IL1R2SNPGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
parkinsion’s disease multiple system atrophy Wnt3 HLA-DRB5 IL1R2 SNP Genetics QH426-470 |
| spellingShingle |
parkinsion’s disease multiple system atrophy Wnt3 HLA-DRB5 IL1R2 SNP Genetics QH426-470 Wei-Ming Su Wei-Ming Su Wei-Ming Su Xiao-Jing Gu Xiao-Jing Gu Xiao-Jing Gu Yan-Bing Hou Yan-Bing Hou Yan-Bing Hou Ling-Yu Zhang Ling-Yu Zhang Ling-Yu Zhang Bei Cao Bei Cao Bei Cao Ru-Wei Ou Ru-Wei Ou Ru-Wei Ou Ying Wu Ying Wu Ying Wu Xue-Ping Chen Xue-Ping Chen Xue-Ping Chen Wei Song Wei Song Wei Song Bi Zhao Bi Zhao Bi Zhao Hui-Fang Shang Hui-Fang Shang Hui-Fang Shang Yong-Ping Chen Yong-Ping Chen Yong-Ping Chen Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy |
| description |
Background: The association between inflammation and neurodegeneration has long been observed in parkinson’s disease (PD) and multiple system atrophy (MSA). Previous genome-wide association studies (GWAS) and meta-analyses have identified several risk loci in inflammation-associated genes associated with PD.Objective: To investigate whether polymorphisms in some inflammation-associated genes could modulate the risk of developing PD and MSA in a Southwest Chinese population.Methods: A total of 2,706 Chinese subjects comprising 1340 PD, 483 MSA and 883 healthy controls were recruited in the study. Three polymorphisms (rs2074404 GG/GT/TT, rs17425622 CC/CT/TT, rs34043159 CC/CT/TT) in genes linked to inflammation in all the subjects were genotyped by using the Sequenom iPLEX Assay.Results: The allele G of WNT3 rs2074404 can increase risk on PD (OR: 1.048, 95% CI: 1.182–1.333, p = 0.006), exclusively in the LOPD subgroup (OR: 1.166, 95% CI:1.025–1.327, p = 0.019), but not in EOPD or MSA. And the recessive model analysis also demonstrated an increased PD risk in GG genotype of this locus (OR = 1.331, p = 0.007). However, no significant differences were observed in the genotype distributions and alleles of HLA-DRB5 rs17425622 and IL1R2 rs34043159 between the PD patients and controls, between the MSA patients and controls, or between subgroups of PD or MSA and controls.Conclusion: Our results suggested the allele G of WNT3 rs2074404 have an adverse effect on PD and particularly, on the LOPD subgroup among a Chinese population. |
| format |
article |
| author |
Wei-Ming Su Wei-Ming Su Wei-Ming Su Xiao-Jing Gu Xiao-Jing Gu Xiao-Jing Gu Yan-Bing Hou Yan-Bing Hou Yan-Bing Hou Ling-Yu Zhang Ling-Yu Zhang Ling-Yu Zhang Bei Cao Bei Cao Bei Cao Ru-Wei Ou Ru-Wei Ou Ru-Wei Ou Ying Wu Ying Wu Ying Wu Xue-Ping Chen Xue-Ping Chen Xue-Ping Chen Wei Song Wei Song Wei Song Bi Zhao Bi Zhao Bi Zhao Hui-Fang Shang Hui-Fang Shang Hui-Fang Shang Yong-Ping Chen Yong-Ping Chen Yong-Ping Chen |
| author_facet |
Wei-Ming Su Wei-Ming Su Wei-Ming Su Xiao-Jing Gu Xiao-Jing Gu Xiao-Jing Gu Yan-Bing Hou Yan-Bing Hou Yan-Bing Hou Ling-Yu Zhang Ling-Yu Zhang Ling-Yu Zhang Bei Cao Bei Cao Bei Cao Ru-Wei Ou Ru-Wei Ou Ru-Wei Ou Ying Wu Ying Wu Ying Wu Xue-Ping Chen Xue-Ping Chen Xue-Ping Chen Wei Song Wei Song Wei Song Bi Zhao Bi Zhao Bi Zhao Hui-Fang Shang Hui-Fang Shang Hui-Fang Shang Yong-Ping Chen Yong-Ping Chen Yong-Ping Chen |
| author_sort |
Wei-Ming Su |
| title |
Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy |
| title_short |
Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy |
| title_full |
Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy |
| title_fullStr |
Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy |
| title_full_unstemmed |
Association Analysis of WNT3, HLA-DRB5 and IL1R2 Polymorphisms in Chinese Patients With Parkinson’s Disease and Multiple System Atrophy |
| title_sort |
association analysis of wnt3, hla-drb5 and il1r2 polymorphisms in chinese patients with parkinson’s disease and multiple system atrophy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/4769c9cc41c445d7bc226fded8a1cedf |
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