Overview of the genetic basis toward early detection of breast cancer

Sumadee De Silva, Kamani Hemamala Tennekoon, Eric Hamilton Karunanayake Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka Abstract: Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common ma...

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Autores principales:	De Silva S, Tennekoon KH, Karunanayake EH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Breast Cancer Genetic Predisposition Early onset Recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/476bd0a48d4442cdb278d6fc1059a42a
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spelling	oai:doaj.org-article:476bd0a48d4442cdb278d6fc1059a42a2021-12-02T07:38:35ZOverview of the genetic basis toward early detection of breast cancer1179-1314https://doaj.org/article/476bd0a48d4442cdb278d6fc1059a42a2019-01-01T00:00:00Zhttps://www.dovepress.com/overview-of-the-genetic-basis-toward-early-detection-of-breast-cancer-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Sumadee De Silva, Kamani Hemamala Tennekoon, Eric Hamilton Karunanayake Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka Abstract: Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common malignancy worldwide among women irrespective of age. As women are an important segment in a community, the weakening of their strength toward the development of a nation is a critical problem in each nation. In this review, it was aimed to discuss the characteristics of cancer genome, cancer genetics, and cancer epigenetics in general and then focus on discussing both genetic and nongenetic factors responsible for the predisposition of breast cancer in humans. More emphasis was placed on genes responsible for the early onset of the disease and which can be used as genetic tools in the identification of the disease at an early stage. Then the context of genetic involvement toward the breast cancer occurrence before age of 40 years was highlighted accordingly. In addition to genetic testing, the review paid adequate attention to mention novel liquid biopsy techniques and other clinical, laboratory, and radiologic assessments. These techniques can be used in early detection and recurrence as well as the surveillance of the patients after primary therapies. Keywords: breast cancer, genetic predisposition, early onset, recurrence  De Silva STennekoon KHKarunanayake EHDove Medical PressarticleBreast CancerGenetic PredispositionEarly onsetRecurrenceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 11, Pp 71-80 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast Cancer Genetic Predisposition Early onset Recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast Cancer Genetic Predisposition Early onset Recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 De Silva S Tennekoon KH Karunanayake EH Overview of the genetic basis toward early detection of breast cancer
description	Sumadee De Silva, Kamani Hemamala Tennekoon, Eric Hamilton Karunanayake Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka Abstract: Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common malignancy worldwide among women irrespective of age. As women are an important segment in a community, the weakening of their strength toward the development of a nation is a critical problem in each nation. In this review, it was aimed to discuss the characteristics of cancer genome, cancer genetics, and cancer epigenetics in general and then focus on discussing both genetic and nongenetic factors responsible for the predisposition of breast cancer in humans. More emphasis was placed on genes responsible for the early onset of the disease and which can be used as genetic tools in the identification of the disease at an early stage. Then the context of genetic involvement toward the breast cancer occurrence before age of 40 years was highlighted accordingly. In addition to genetic testing, the review paid adequate attention to mention novel liquid biopsy techniques and other clinical, laboratory, and radiologic assessments. These techniques can be used in early detection and recurrence as well as the surveillance of the patients after primary therapies. Keywords: breast cancer, genetic predisposition, early onset, recurrence
format	article
author	De Silva S Tennekoon KH Karunanayake EH
author_facet	De Silva S Tennekoon KH Karunanayake EH
author_sort	De Silva S
title	Overview of the genetic basis toward early detection of breast cancer
title_short	Overview of the genetic basis toward early detection of breast cancer
title_full	Overview of the genetic basis toward early detection of breast cancer
title_fullStr	Overview of the genetic basis toward early detection of breast cancer
title_full_unstemmed	Overview of the genetic basis toward early detection of breast cancer
title_sort	overview of the genetic basis toward early detection of breast cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/476bd0a48d4442cdb278d6fc1059a42a
work_keys_str_mv	AT desilvas overviewofthegeneticbasistowardearlydetectionofbreastcancer AT tennekoonkh overviewofthegeneticbasistowardearlydetectionofbreastcancer AT karunanayakeeh overviewofthegeneticbasistowardearlydetectionofbreastcancer
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Overview of the genetic basis toward early detection of breast cancer

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