CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus

Abstract The correlation between copy number variation (CNV) and the susceptibility to systemic lupus erythematosus (SLE) has been reported for various immunity-related genes. However, the contribution of CNVs to SLE susceptibility awaits more investigation. To evaluate the copy numbers in immunity-...

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Autores principales:	Young-Ho Kim, Eunyoung Emily Lee, Hye-Won Sim, Eun-Kyung Kang, Yoon-Ho Won, Dong-eun Lee, Kyeong-Man Hong, Yeong-Wook Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/476cd58f043043d6a01ce297736735e1
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spelling	oai:doaj.org-article:476cd58f043043d6a01ce297736735e12021-12-02T19:17:05ZCCL3L3-null status is associated with susceptibility to systemic lupus erythematosus10.1038/s41598-021-98531-62045-2322https://doaj.org/article/476cd58f043043d6a01ce297736735e12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98531-6https://doaj.org/toc/2045-2322Abstract The correlation between copy number variation (CNV) and the susceptibility to systemic lupus erythematosus (SLE) has been reported for various immunity-related genes. However, the contribution of CNVs to SLE susceptibility awaits more investigation. To evaluate the copy numbers in immunity-related genes such as TNFAIP3, TNIP1, IL12B, TBX21 (T-bet), TLR7, C4A, C4B, CCL3L1, and CCL3L3, the modified real competitive polymerase chain reaction (mrcPCR) assay was employed, and the association between the copy numbers and SLE susceptibility was analyzed in 334 SLE patients and 338 controls. CCL3L3-null status was significantly associated with SLE susceptibility (OR > 18, P < 0.0001), which remained significant by Bonferroni’s correction (corrected P = 0.0007). However, the significant association between C4B low-copy status and SLE susceptibility (OR = 1.6051, P = 0.0331) became non-significant by Bonferroni’s correction (corrected P = 0.3938). Except for these results, no other significant association between SLE susceptibility and copy number status in other genes was observed. The CCL3L3-null status may be a significant factor for SLE susceptibility.Young-Ho KimEunyoung Emily LeeHye-Won SimEun-Kyung KangYoon-Ho WonDong-eun LeeKyeong-Man HongYeong-Wook SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young-Ho Kim Eunyoung Emily Lee Hye-Won Sim Eun-Kyung Kang Yoon-Ho Won Dong-eun Lee Kyeong-Man Hong Yeong-Wook Song CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus
description	Abstract The correlation between copy number variation (CNV) and the susceptibility to systemic lupus erythematosus (SLE) has been reported for various immunity-related genes. However, the contribution of CNVs to SLE susceptibility awaits more investigation. To evaluate the copy numbers in immunity-related genes such as TNFAIP3, TNIP1, IL12B, TBX21 (T-bet), TLR7, C4A, C4B, CCL3L1, and CCL3L3, the modified real competitive polymerase chain reaction (mrcPCR) assay was employed, and the association between the copy numbers and SLE susceptibility was analyzed in 334 SLE patients and 338 controls. CCL3L3-null status was significantly associated with SLE susceptibility (OR > 18, P < 0.0001), which remained significant by Bonferroni’s correction (corrected P = 0.0007). However, the significant association between C4B low-copy status and SLE susceptibility (OR = 1.6051, P = 0.0331) became non-significant by Bonferroni’s correction (corrected P = 0.3938). Except for these results, no other significant association between SLE susceptibility and copy number status in other genes was observed. The CCL3L3-null status may be a significant factor for SLE susceptibility.
format	article
author	Young-Ho Kim Eunyoung Emily Lee Hye-Won Sim Eun-Kyung Kang Yoon-Ho Won Dong-eun Lee Kyeong-Man Hong Yeong-Wook Song
author_facet	Young-Ho Kim Eunyoung Emily Lee Hye-Won Sim Eun-Kyung Kang Yoon-Ho Won Dong-eun Lee Kyeong-Man Hong Yeong-Wook Song
author_sort	Young-Ho Kim
title	CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus
title_short	CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus
title_full	CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus
title_fullStr	CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus
title_full_unstemmed	CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus
title_sort	ccl3l3-null status is associated with susceptibility to systemic lupus erythematosus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/476cd58f043043d6a01ce297736735e1
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CCL3L3-null status is associated with susceptibility to systemic lupus erythematosus

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