Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications

Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biologica...

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Auteurs principaux:	Michela Saviana, Giulia Romano, Patricia Le, Mario Acunzo, Patrick Nana-Sinkam
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	extracellular vesicles metastasis lung cancer non-coding RNA therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Accès en ligne:	https://doaj.org/article/476fcc03045142a99dd13a3fe751746a
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spelling	oai:doaj.org-article:476fcc03045142a99dd13a3fe751746a2021-11-25T17:01:52ZExtracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications10.3390/cancers132256332072-6694https://doaj.org/article/476fcc03045142a99dd13a3fe751746a2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5633https://doaj.org/toc/2072-6694Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers.Michela SavianaGiulia RomanoPatricia LeMario AcunzoPatrick Nana-SinkamMDPI AGarticleextracellular vesiclesmetastasislung cancernon-coding RNAtherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5633, p 5633 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles metastasis lung cancer non-coding RNA therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	extracellular vesicles metastasis lung cancer non-coding RNA therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Michela Saviana Giulia Romano Patricia Le Mario Acunzo Patrick Nana-Sinkam Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
description	Extracellular vesicles (EVs) are heterogenous membrane-encapsulated vesicles secreted by every cell into the extracellular environment. EVs carry bioactive molecules, including proteins, lipids, DNA, and different RNA forms, which can be internalized by recipient cells, thus altering their biological characteristics. Given that EVs are commonly found in most body fluids, they have been widely described as mediators of communication in several physiological and pathological processes, including cancer. Moreover, their easy detection in biofluids makes them potentially useful candidates as tumor biomarkers. In this manuscript, we review the current knowledge regarding EVs and non-coding RNAs and their role as drivers of the metastatic process in lung cancer. Furthermore, we present the most recent applications for EVs and non-coding RNAs as cancer therapeutics and their relevance as clinical biomarkers.
format	article
author	Michela Saviana Giulia Romano Patricia Le Mario Acunzo Patrick Nana-Sinkam
author_facet	Michela Saviana Giulia Romano Patricia Le Mario Acunzo Patrick Nana-Sinkam
author_sort	Michela Saviana
title	Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
title_short	Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
title_full	Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
title_fullStr	Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
title_full_unstemmed	Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
title_sort	extracellular vesicles in lung cancer metastasis and their clinical applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/476fcc03045142a99dd13a3fe751746a
work_keys_str_mv	AT michelasaviana extracellularvesiclesinlungcancermetastasisandtheirclinicalapplications AT giuliaromano extracellularvesiclesinlungcancermetastasisandtheirclinicalapplications AT patriciale extracellularvesiclesinlungcancermetastasisandtheirclinicalapplications AT marioacunzo extracellularvesiclesinlungcancermetastasisandtheirclinicalapplications AT patricknanasinkam extracellularvesiclesinlungcancermetastasisandtheirclinicalapplications
_version_	1718412772456267776

Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications

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