Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis

Anthrax bacteria: a step in the pathway to biofilms An enzyme that adds phosphate groups to other proteins, PrkC, mediates molecular signaling events that allow anthrax bacteria to form biofilms. Bacillus anthracis is widely used as a model to explore the formation of biofilms that allows many bacte...

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Autores principales:	Gunjan Arora, Andaleeb Sajid, Richa Virmani, Anshika Singhal, C. M. Santosh Kumar, Neha Dhasmana, Tanya Khanna, Abhijit Maji, Richa Misra, Virginie Molle, Dörte Becher, Ulf Gerth, Shekhar C. Mande, Yogendra Singh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/4771965309c44fcba1e5d398d3205615
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spelling	oai:doaj.org-article:4771965309c44fcba1e5d398d32056152021-12-02T15:10:26ZSer/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis10.1038/s41522-017-0015-42055-5008https://doaj.org/article/4771965309c44fcba1e5d398d32056152017-03-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0015-4https://doaj.org/toc/2055-5008Anthrax bacteria: a step in the pathway to biofilms An enzyme that adds phosphate groups to other proteins, PrkC, mediates molecular signaling events that allow anthrax bacteria to form biofilms. Bacillus anthracis is widely used as a model to explore the formation of biofilms that allows many bacterial infections to resist immune defenses. An international research team led by Yogendra Singh and Andaleeb Sajid at the CSIR-Institute of Genomics and Integrative Biology in Delhi, India, studied the bacterial protein kinase PrkC. The researchers found that PrkC phosphorylates a “chaperone” protein that assist the assembly and disassembly of other protein-based structures. This signaling protein and the chaperone help in biofilm formation. Establishing this link in the signaling chain leading to biofilms will guide future research to combat the role of biofilms in disease.Gunjan AroraAndaleeb SajidRicha VirmaniAnshika SinghalC. M. Santosh KumarNeha DhasmanaTanya KhannaAbhijit MajiRicha MisraVirginie MolleDörte BecherUlf GerthShekhar C. MandeYogendra SinghNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Gunjan Arora Andaleeb Sajid Richa Virmani Anshika Singhal C. M. Santosh Kumar Neha Dhasmana Tanya Khanna Abhijit Maji Richa Misra Virginie Molle Dörte Becher Ulf Gerth Shekhar C. Mande Yogendra Singh Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
description	Anthrax bacteria: a step in the pathway to biofilms An enzyme that adds phosphate groups to other proteins, PrkC, mediates molecular signaling events that allow anthrax bacteria to form biofilms. Bacillus anthracis is widely used as a model to explore the formation of biofilms that allows many bacterial infections to resist immune defenses. An international research team led by Yogendra Singh and Andaleeb Sajid at the CSIR-Institute of Genomics and Integrative Biology in Delhi, India, studied the bacterial protein kinase PrkC. The researchers found that PrkC phosphorylates a “chaperone” protein that assist the assembly and disassembly of other protein-based structures. This signaling protein and the chaperone help in biofilm formation. Establishing this link in the signaling chain leading to biofilms will guide future research to combat the role of biofilms in disease.
format	article
author	Gunjan Arora Andaleeb Sajid Richa Virmani Anshika Singhal C. M. Santosh Kumar Neha Dhasmana Tanya Khanna Abhijit Maji Richa Misra Virginie Molle Dörte Becher Ulf Gerth Shekhar C. Mande Yogendra Singh
author_facet	Gunjan Arora Andaleeb Sajid Richa Virmani Anshika Singhal C. M. Santosh Kumar Neha Dhasmana Tanya Khanna Abhijit Maji Richa Misra Virginie Molle Dörte Becher Ulf Gerth Shekhar C. Mande Yogendra Singh
author_sort	Gunjan Arora
title	Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
title_short	Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
title_full	Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
title_fullStr	Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
title_full_unstemmed	Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
title_sort	ser/thr protein kinase prkc-mediated regulation of groel is critical for biofilm formation in bacillus anthracis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4771965309c44fcba1e5d398d3205615
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Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis

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