Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain

Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most neurodegenerative diseases are associated with impaired spatial working memory and anxiety-like behavior. Thus, it is important to understand the underlying cellular mechanisms of...

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Autores principales:	Dhondup Namgyal, Sher Ali, Muhammad Delwar Hussain, Mohsin Kazi, Ajaz Ahmad, Maryam Sarwat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	curcumin cadmium inflammation oxidative stress spatial working memory Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/47753a0cc283401cb223d9f65dac15bf
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spelling	oai:doaj.org-article:47753a0cc283401cb223d9f65dac15bf2021-11-25T16:26:53ZCurcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain10.3390/antiox101117102076-3921https://doaj.org/article/47753a0cc283401cb223d9f65dac15bf2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1710https://doaj.org/toc/2076-3921Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most neurodegenerative diseases are associated with impaired spatial working memory and anxiety-like behavior. Thus, it is important to understand the underlying cellular mechanisms of neurodegenerative diseases in different regions of the brain to develop an effective therapeutic approach. In our previous research paper, we have reported the ameliorative effect of curcumin in Cd-induced hippocampal neurodegeneration. However, recently many researchers had reported the important role of the prefrontal cortex in higher cognitive functions. Therefore, to look into the cellular mechanism of curcumin protection against Cd-induced prefrontal cortex neurotoxicity, we investigated spatial working memory, anxiety-like behavior and analyzed prefrontal cortex inflammatory markers (IL-6, IL-10, and TNFα), antioxidant enzymes (SOD, GSH, and CAT), and pro-oxidant MDA level. Further, we conducted histological studies of the prefrontal cortex in Swiss albino mice exposed to cadmium (2.5 mg/kg). We observed that curcumin treatment improved the spatial working memory and anxiety-like behavior of mice through reduction of prefrontal cortex neuroinflammation and oxidative stress as well as increasing the number of viable prefrontal cortex neuronal cells. Our result suggests that environmental heavy metal cadmium can induce behavioral impairment in mice through prefrontal cortex cellular inflammation and oxidative stress. We found that curcumin has a potential therapeutic property to mitigate these behavioral and biochemical impairments induced by cadmium.Dhondup NamgyalSher AliMuhammad Delwar HussainMohsin KaziAjaz AhmadMaryam SarwatMDPI AGarticlecurcumincadmiuminflammationoxidative stressspatial working memoryTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1710, p 1710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin cadmium inflammation oxidative stress spatial working memory Therapeutics. Pharmacology RM1-950
spellingShingle	curcumin cadmium inflammation oxidative stress spatial working memory Therapeutics. Pharmacology RM1-950 Dhondup Namgyal Sher Ali Muhammad Delwar Hussain Mohsin Kazi Ajaz Ahmad Maryam Sarwat Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
description	Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most neurodegenerative diseases are associated with impaired spatial working memory and anxiety-like behavior. Thus, it is important to understand the underlying cellular mechanisms of neurodegenerative diseases in different regions of the brain to develop an effective therapeutic approach. In our previous research paper, we have reported the ameliorative effect of curcumin in Cd-induced hippocampal neurodegeneration. However, recently many researchers had reported the important role of the prefrontal cortex in higher cognitive functions. Therefore, to look into the cellular mechanism of curcumin protection against Cd-induced prefrontal cortex neurotoxicity, we investigated spatial working memory, anxiety-like behavior and analyzed prefrontal cortex inflammatory markers (IL-6, IL-10, and TNFα), antioxidant enzymes (SOD, GSH, and CAT), and pro-oxidant MDA level. Further, we conducted histological studies of the prefrontal cortex in Swiss albino mice exposed to cadmium (2.5 mg/kg). We observed that curcumin treatment improved the spatial working memory and anxiety-like behavior of mice through reduction of prefrontal cortex neuroinflammation and oxidative stress as well as increasing the number of viable prefrontal cortex neuronal cells. Our result suggests that environmental heavy metal cadmium can induce behavioral impairment in mice through prefrontal cortex cellular inflammation and oxidative stress. We found that curcumin has a potential therapeutic property to mitigate these behavioral and biochemical impairments induced by cadmium.
format	article
author	Dhondup Namgyal Sher Ali Muhammad Delwar Hussain Mohsin Kazi Ajaz Ahmad Maryam Sarwat
author_facet	Dhondup Namgyal Sher Ali Muhammad Delwar Hussain Mohsin Kazi Ajaz Ahmad Maryam Sarwat
author_sort	Dhondup Namgyal
title	Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
title_short	Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
title_full	Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
title_fullStr	Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
title_full_unstemmed	Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain
title_sort	curcumin ameliorates the cd-induced anxiety-like behavior in mice by regulating oxidative stress and neuro-inflammatory proteins in the prefrontal cortex region of the brain
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/47753a0cc283401cb223d9f65dac15bf
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Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain

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