New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation

Abstract The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. How...

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Autores principales:	Agata Mata, Vanessa Gil, Jeús Pérez-Clausell, Miguel Dasilva, Mari Carmen González-Calixto, Eduardo Soriano, José Manuel García-Verdugo, Maria V. Sanchez-Vives, José Antonio del Río
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47774103a93944e5bb751e7e4990acb8
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spelling	oai:doaj.org-article:47774103a93944e5bb751e7e4990acb82021-12-02T15:08:55ZNew functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation10.1038/s41598-018-19794-02045-2322https://doaj.org/article/47774103a93944e5bb751e7e4990acb82018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19794-0https://doaj.org/toc/2045-2322Abstract The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of most of their family members have been described, very few data about the participation of Semaphorin 3E (Sema3E) and its receptor PlexinD1 during the development and maturation of the entorhino-hippocampal (EH) connection are available. In the present study, we focused on determining their roles both during development and in adulthood. We determined a relevant role for Sema3E/PlexinD1 in the layer-specific development of the EH connection. Indeed, mice lacking Sema3E/PlexinD1 signalling showed aberrant layering of entorhinal axons in the hippocampus during embryonic and perinatal stages. In addition, absence of Sema3E/PlexinD1 signalling results in further changes in postnatal and adult hippocampal formation, such as numerous misrouted ectopic mossy fibers. More relevantly, we describe how subgranular cells express PlexinD1 and how the absence of Sema3E induces a dysregulation of the proliferation of dentate gyrus progenitors leading to the presence of ectopic cells in the molecular layer. Lastly, Sema3E mutant mice displayed increased network excitability both in the dentate gyrus and the hippocampus proper.Agata MataVanessa GilJeús Pérez-ClausellMiguel DasilvaMari Carmen González-CalixtoEduardo SorianoJosé Manuel García-VerdugoMaria V. Sanchez-VivesJosé Antonio del RíoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agata Mata Vanessa Gil Jeús Pérez-Clausell Miguel Dasilva Mari Carmen González-Calixto Eduardo Soriano José Manuel García-Verdugo Maria V. Sanchez-Vives José Antonio del Río New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
description	Abstract The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of most of their family members have been described, very few data about the participation of Semaphorin 3E (Sema3E) and its receptor PlexinD1 during the development and maturation of the entorhino-hippocampal (EH) connection are available. In the present study, we focused on determining their roles both during development and in adulthood. We determined a relevant role for Sema3E/PlexinD1 in the layer-specific development of the EH connection. Indeed, mice lacking Sema3E/PlexinD1 signalling showed aberrant layering of entorhinal axons in the hippocampus during embryonic and perinatal stages. In addition, absence of Sema3E/PlexinD1 signalling results in further changes in postnatal and adult hippocampal formation, such as numerous misrouted ectopic mossy fibers. More relevantly, we describe how subgranular cells express PlexinD1 and how the absence of Sema3E induces a dysregulation of the proliferation of dentate gyrus progenitors leading to the presence of ectopic cells in the molecular layer. Lastly, Sema3E mutant mice displayed increased network excitability both in the dentate gyrus and the hippocampus proper.
format	article
author	Agata Mata Vanessa Gil Jeús Pérez-Clausell Miguel Dasilva Mari Carmen González-Calixto Eduardo Soriano José Manuel García-Verdugo Maria V. Sanchez-Vives José Antonio del Río
author_facet	Agata Mata Vanessa Gil Jeús Pérez-Clausell Miguel Dasilva Mari Carmen González-Calixto Eduardo Soriano José Manuel García-Verdugo Maria V. Sanchez-Vives José Antonio del Río
author_sort	Agata Mata
title	New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
title_short	New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
title_full	New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
title_fullStr	New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
title_full_unstemmed	New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation
title_sort	new functions of semaphorin 3e and its receptor plexind1 during developing and adult hippocampal formation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/47774103a93944e5bb751e7e4990acb8
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New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation

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