GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

The extracellular cues regulating filamentous actin formation in somatic cell nuclei are unclear. Here, the authors show that activated GPCR signalling initiates transient accumulation of nuclear F-actin/formation in nuclear actin filaments, driven by calcium and requiring the nucleator Formin INF2.

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Autores principales:	Ying Wang, Alice Sherrard, Bing Zhao, Michael Melak, Jonathan Trautwein, Eva-Maria Kleinschnitz, Nikolaos Tsopoulidis, Oliver T. Fackler, Carsten Schwan, Robert Grosse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/477762cae7a74472b52ca7e0b0fd420c
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spelling	oai:doaj.org-article:477762cae7a74472b52ca7e0b0fd420c2021-12-02T15:35:48ZGPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics10.1038/s41467-019-13322-y2041-1723https://doaj.org/article/477762cae7a74472b52ca7e0b0fd420c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13322-yhttps://doaj.org/toc/2041-1723The extracellular cues regulating filamentous actin formation in somatic cell nuclei are unclear. Here, the authors show that activated GPCR signalling initiates transient accumulation of nuclear F-actin/formation in nuclear actin filaments, driven by calcium and requiring the nucleator Formin INF2.Ying WangAlice SherrardBing ZhaoMichael MelakJonathan TrautweinEva-Maria KleinschnitzNikolaos TsopoulidisOliver T. FacklerCarsten SchwanRobert GrosseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Wang Alice Sherrard Bing Zhao Michael Melak Jonathan Trautwein Eva-Maria Kleinschnitz Nikolaos Tsopoulidis Oliver T. Fackler Carsten Schwan Robert Grosse GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
description	The extracellular cues regulating filamentous actin formation in somatic cell nuclei are unclear. Here, the authors show that activated GPCR signalling initiates transient accumulation of nuclear F-actin/formation in nuclear actin filaments, driven by calcium and requiring the nucleator Formin INF2.
format	article
author	Ying Wang Alice Sherrard Bing Zhao Michael Melak Jonathan Trautwein Eva-Maria Kleinschnitz Nikolaos Tsopoulidis Oliver T. Fackler Carsten Schwan Robert Grosse
author_facet	Ying Wang Alice Sherrard Bing Zhao Michael Melak Jonathan Trautwein Eva-Maria Kleinschnitz Nikolaos Tsopoulidis Oliver T. Fackler Carsten Schwan Robert Grosse
author_sort	Ying Wang
title	GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
title_short	GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
title_full	GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
title_fullStr	GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
title_full_unstemmed	GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
title_sort	gpcr-induced calcium transients trigger nuclear actin assembly for chromatin dynamics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/477762cae7a74472b52ca7e0b0fd420c
work_keys_str_mv	AT yingwang gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT alicesherrard gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT bingzhao gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT michaelmelak gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT jonathantrautwein gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT evamariakleinschnitz gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT nikolaostsopoulidis gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT olivertfackler gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT carstenschwan gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics AT robertgrosse gpcrinducedcalciumtransientstriggernuclearactinassemblyforchromatindynamics
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GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

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