Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.

Lung cancer (LC) is a malignant tumor that poses the greatest threat to human health and life. Most studies suggested that the occurrence of LC is associated with environmental and genetic factors. We aimed to explore the association between COL6A4P2 single nucleotide polymorphisms (SNPs) and CHD ri...

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Autores principales:	Xiaodong Dang, Wenhui Zhao, Chen Li, Hua Yang, Dianzhen Li, Shanshan Zhang, Tianbo Jin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/477b12dc72794427a425ddc278ad4b0a
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spelling	oai:doaj.org-article:477b12dc72794427a425ddc278ad4b0a2021-12-02T20:11:15ZImpact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.1932-620310.1371/journal.pone.0252082https://doaj.org/article/477b12dc72794427a425ddc278ad4b0a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252082https://doaj.org/toc/1932-6203Lung cancer (LC) is a malignant tumor that poses the greatest threat to human health and life. Most studies suggested that the occurrence of LC is associated with environmental and genetic factors. We aimed to explore the association between COL6A4P2 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population. Based on the 'case-control' experimental design (510 cases and 495 controls), we conducted an association study between five candidate COL6A4P2 SNPs and the corresponding LC risk. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression to analyze the LC susceptibility under different genetic models. The results showed that COL6A4P2 rs34445363 was significantly associated with LC risk under alleles model (OR = 1.26, 95%CI: 1.01-1.58, p = 0.038). In addition, rs34445363 was also significantly associated with LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01-1.58, p = 0.041). The results of subgroup analysis showed that rs34445363 (OR = 1.42, 95%CI: 1.03-1.95, p = 0.033) and rs61733464 (OR = 0.72, 95%CI: 0.52-0.99, p = 0.048) were both significantly associated with LC risk in the log-additive model among participants who were ≤ 61 years old. We also found that the variation of rs34445363 (GA vs. GG, OR = 1.73, 95%CI: 1.04-2.86, p = 0.034) and rs77941834 (TA vs. TT, OR = 1.88, 95%CI: 1.06-3.34, p = 0.032) were associated with LC risk in the codominant model among female participants. Our study is the first to find that COL6A4P2 gene polymorphism is associated with LC risk in the Chinese Han population. Our study provides a basic reference for individualized LC prevention.Xiaodong DangWenhui ZhaoChen LiHua YangDianzhen LiShanshan ZhangTianbo JinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252082 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaodong Dang Wenhui Zhao Chen Li Hua Yang Dianzhen Li Shanshan Zhang Tianbo Jin Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.
description	Lung cancer (LC) is a malignant tumor that poses the greatest threat to human health and life. Most studies suggested that the occurrence of LC is associated with environmental and genetic factors. We aimed to explore the association between COL6A4P2 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population. Based on the 'case-control' experimental design (510 cases and 495 controls), we conducted an association study between five candidate COL6A4P2 SNPs and the corresponding LC risk. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression to analyze the LC susceptibility under different genetic models. The results showed that COL6A4P2 rs34445363 was significantly associated with LC risk under alleles model (OR = 1.26, 95%CI: 1.01-1.58, p = 0.038). In addition, rs34445363 was also significantly associated with LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01-1.58, p = 0.041). The results of subgroup analysis showed that rs34445363 (OR = 1.42, 95%CI: 1.03-1.95, p = 0.033) and rs61733464 (OR = 0.72, 95%CI: 0.52-0.99, p = 0.048) were both significantly associated with LC risk in the log-additive model among participants who were ≤ 61 years old. We also found that the variation of rs34445363 (GA vs. GG, OR = 1.73, 95%CI: 1.04-2.86, p = 0.034) and rs77941834 (TA vs. TT, OR = 1.88, 95%CI: 1.06-3.34, p = 0.032) were associated with LC risk in the codominant model among female participants. Our study is the first to find that COL6A4P2 gene polymorphism is associated with LC risk in the Chinese Han population. Our study provides a basic reference for individualized LC prevention.
format	article
author	Xiaodong Dang Wenhui Zhao Chen Li Hua Yang Dianzhen Li Shanshan Zhang Tianbo Jin
author_facet	Xiaodong Dang Wenhui Zhao Chen Li Hua Yang Dianzhen Li Shanshan Zhang Tianbo Jin
author_sort	Xiaodong Dang
title	Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.
title_short	Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.
title_full	Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.
title_fullStr	Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.
title_full_unstemmed	Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.
title_sort	impact of col6a4p2 gene polymorphisms on the risk of lung cancer: a case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/477b12dc72794427a425ddc278ad4b0a
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Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer: A case-control study.

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