Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training

Abstract Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which is possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated the short-term effects of exercise, to determine if a 1-week intervention is suff...

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Autores principales:	J. J. Steventon, H. L. Chandler, C. Foster, H. Dingsdale, M. Germuska, T. Massey, G. Parker, R. G. Wise, K. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47808eb419c14e0fa8b9c6a8cb36d45e
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spelling	oai:doaj.org-article:47808eb419c14e0fa8b9c6a8cb36d45e2021-11-14T12:17:31ZChanges in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training10.1038/s41598-021-01630-72045-2322https://doaj.org/article/47808eb419c14e0fa8b9c6a8cb36d45e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01630-7https://doaj.org/toc/2045-2322Abstract Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which is possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated the short-term effects of exercise, to determine if a 1-week intervention is sufficient to induce brain changes. Fifteen healthy young males completed five supervised exercise training sessions over seven days. This was preceded and followed by a multi-modal magnetic resonance imaging (MRI) scan (diffusion-weighted MRI, perfusion-weighted MRI, dual-calibrated functional MRI) acquired 1 week apart, and blood sampling for BDNF. A diffusion tractography analysis showed, after exercise, a significant reduction relative to baseline in restricted fraction—an axon-specific metric—in the corpus callosum, uncinate fasciculus, and parahippocampal cingulum. A voxel-based approach found an increase in fractional anisotropy and reduction in radial diffusivity symmetrically, in voxels predominantly localised in the corpus callosum. A selective increase in hippocampal blood flow was found following exercise, with no change in vascular reactivity. BDNF levels were not altered. Thus, we demonstrate that 1 week of exercise is sufficient to induce microstructural and vascular brain changes on a group level, independent of BDNF, providing new insight into the temporal dynamics of plasticity, necessary to exploit the therapeutic potential of exercise.J. J. SteventonH. L. ChandlerC. FosterH. DingsdaleM. GermuskaT. MasseyG. ParkerR. G. WiseK. MurphyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. J. Steventon H. L. Chandler C. Foster H. Dingsdale M. Germuska T. Massey G. Parker R. G. Wise K. Murphy Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
description	Abstract Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which is possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated the short-term effects of exercise, to determine if a 1-week intervention is sufficient to induce brain changes. Fifteen healthy young males completed five supervised exercise training sessions over seven days. This was preceded and followed by a multi-modal magnetic resonance imaging (MRI) scan (diffusion-weighted MRI, perfusion-weighted MRI, dual-calibrated functional MRI) acquired 1 week apart, and blood sampling for BDNF. A diffusion tractography analysis showed, after exercise, a significant reduction relative to baseline in restricted fraction—an axon-specific metric—in the corpus callosum, uncinate fasciculus, and parahippocampal cingulum. A voxel-based approach found an increase in fractional anisotropy and reduction in radial diffusivity symmetrically, in voxels predominantly localised in the corpus callosum. A selective increase in hippocampal blood flow was found following exercise, with no change in vascular reactivity. BDNF levels were not altered. Thus, we demonstrate that 1 week of exercise is sufficient to induce microstructural and vascular brain changes on a group level, independent of BDNF, providing new insight into the temporal dynamics of plasticity, necessary to exploit the therapeutic potential of exercise.
format	article
author	J. J. Steventon H. L. Chandler C. Foster H. Dingsdale M. Germuska T. Massey G. Parker R. G. Wise K. Murphy
author_facet	J. J. Steventon H. L. Chandler C. Foster H. Dingsdale M. Germuska T. Massey G. Parker R. G. Wise K. Murphy
author_sort	J. J. Steventon
title	Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
title_short	Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
title_full	Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
title_fullStr	Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
title_full_unstemmed	Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
title_sort	changes in white matter microstructure and mri-derived cerebral blood flow after 1-week of exercise training
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47808eb419c14e0fa8b9c6a8cb36d45e
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Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training

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