Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.

Cortical synchronization during NREM sleep, characterized by electroencephalographic slow waves (SW <4 Hz and >75 µV), is strongly related to the number of hours of wakefulness prior to sleep and to the quality of the waking experience. Whether a similar increase in wakefulness length leads to...

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Autores principales:	Marjolaine Lafortune, Jean-François Gagnon, Véronique Latreille, Gilles Vandewalle, Nicolas Martin, Daniel Filipini, Julien Doyon, Julie Carrier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47816d0d69d44314947401c3281617f2
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spelling	oai:doaj.org-article:47816d0d69d44314947401c3281617f22021-11-18T07:08:53ZReduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.1932-620310.1371/journal.pone.0043224https://doaj.org/article/47816d0d69d44314947401c3281617f22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912833/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cortical synchronization during NREM sleep, characterized by electroencephalographic slow waves (SW <4 Hz and >75 µV), is strongly related to the number of hours of wakefulness prior to sleep and to the quality of the waking experience. Whether a similar increase in wakefulness length leads to a comparable enhancement in NREM sleep cortical synchronization in young and older subjects is still a matter of debate in the literature. Here we evaluated the impact of 25-hours of wakefulness on SW during a daytime recovery sleep episode in 29 young (27 y ± 5), and 34 middle-aged (51 y ± 5) subjects. We also assessed whether age-related changes in NREM sleep cortical synchronization predicts the ability to maintain sleep during daytime recovery sleep. Compared to baseline sleep, sleep efficiency was lower during daytime recovery sleep in both age-groups but the effect was more prominent in the middle-aged than in the young subjects. In both age groups, SW density, amplitude, and slope increased whereas SW positive and negative phase duration decreased during daytime recovery sleep compared to baseline sleep, particularly in anterior brain areas. Importantly, compared to young subjects, middle-aged participants showed lower SW density rebound and SW positive phase duration enhancement after sleep deprivation during daytime recovery sleep. Furthermore, middle-aged subjects showed lower SW amplitude and slope enhancements after sleep deprivation than young subjects in frontal and prefrontal derivations only. None of the SW characteristics at baseline were associated with daytime recovery sleep efficiency. Our results support the notion that anterior brain areas elicit and may necessitate more intense recovery and that aging reduces enhancement of cortical synchronization after sleep loss, particularly in these areas. Age-related changes in the quality of wake experience may underlie age-related reduction in markers of cortical synchronization enhancement after sustained wakefulness.Marjolaine LafortuneJean-François GagnonVéronique LatreilleGilles VandewalleNicolas MartinDaniel FilipiniJulien DoyonJulie CarrierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43224 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marjolaine Lafortune Jean-François Gagnon Véronique Latreille Gilles Vandewalle Nicolas Martin Daniel Filipini Julien Doyon Julie Carrier Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
description	Cortical synchronization during NREM sleep, characterized by electroencephalographic slow waves (SW <4 Hz and >75 µV), is strongly related to the number of hours of wakefulness prior to sleep and to the quality of the waking experience. Whether a similar increase in wakefulness length leads to a comparable enhancement in NREM sleep cortical synchronization in young and older subjects is still a matter of debate in the literature. Here we evaluated the impact of 25-hours of wakefulness on SW during a daytime recovery sleep episode in 29 young (27 y ± 5), and 34 middle-aged (51 y ± 5) subjects. We also assessed whether age-related changes in NREM sleep cortical synchronization predicts the ability to maintain sleep during daytime recovery sleep. Compared to baseline sleep, sleep efficiency was lower during daytime recovery sleep in both age-groups but the effect was more prominent in the middle-aged than in the young subjects. In both age groups, SW density, amplitude, and slope increased whereas SW positive and negative phase duration decreased during daytime recovery sleep compared to baseline sleep, particularly in anterior brain areas. Importantly, compared to young subjects, middle-aged participants showed lower SW density rebound and SW positive phase duration enhancement after sleep deprivation during daytime recovery sleep. Furthermore, middle-aged subjects showed lower SW amplitude and slope enhancements after sleep deprivation than young subjects in frontal and prefrontal derivations only. None of the SW characteristics at baseline were associated with daytime recovery sleep efficiency. Our results support the notion that anterior brain areas elicit and may necessitate more intense recovery and that aging reduces enhancement of cortical synchronization after sleep loss, particularly in these areas. Age-related changes in the quality of wake experience may underlie age-related reduction in markers of cortical synchronization enhancement after sustained wakefulness.
format	article
author	Marjolaine Lafortune Jean-François Gagnon Véronique Latreille Gilles Vandewalle Nicolas Martin Daniel Filipini Julien Doyon Julie Carrier
author_facet	Marjolaine Lafortune Jean-François Gagnon Véronique Latreille Gilles Vandewalle Nicolas Martin Daniel Filipini Julien Doyon Julie Carrier
author_sort	Marjolaine Lafortune
title	Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
title_short	Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
title_full	Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
title_fullStr	Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
title_full_unstemmed	Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
title_sort	reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/47816d0d69d44314947401c3281617f2
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Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects.

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