Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing

In this study, we report a flexible implantable 4-channel microelectrode probe coated with highly porous and robust nanocomposite of poly (3,4-ethylenedioxythiophene) (PEDOT) and carbon nanofiber (CNF) as a solid doping template for high-performance in vivo neuronal recording and stimulation. A simp...

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Autores principales:	Venkata Suresh Vajrala, Valentin Saunier, Lionel G. Nowak, Emmanuel Flahaut, Christian Bergaud, Ali Maziz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PEDOT-Carbon carbon nanofibers porous composite flexible neural interfaces electrophysiological recording neural stimulation Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/4782fd51761b4516b07546291a07c212
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spelling	oai:doaj.org-article:4782fd51761b4516b07546291a07c2122021-12-01T08:12:16ZNanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing2296-418510.3389/fbioe.2021.780197https://doaj.org/article/4782fd51761b4516b07546291a07c2122021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.780197/fullhttps://doaj.org/toc/2296-4185In this study, we report a flexible implantable 4-channel microelectrode probe coated with highly porous and robust nanocomposite of poly (3,4-ethylenedioxythiophene) (PEDOT) and carbon nanofiber (CNF) as a solid doping template for high-performance in vivo neuronal recording and stimulation. A simple yet well-controlled deposition strategy was developed via in situ electrochemical polymerization technique to create a porous network of PEDOT and CNFs on a flexible 4-channel gold microelectrode probe. Different morphological and electrochemical characterizations showed that they exhibit remarkable and superior electrochemical properties, yielding microelectrodes combining high surface area, low impedance (16.8 ± 2 MΩ µm2 at 1 kHz) and elevated charge injection capabilities (7.6 ± 1.3 mC/cm2) that exceed those of pure and composite PEDOT layers. In addition, the PEDOT-CNF composite electrode exhibited extended biphasic charge cycle endurance and excellent performance under accelerated lifetime testing, resulting in a negligible physical delamination and/or degradation for long periods of electrical stimulation. In vitro testing on mouse brain slices showed that they can record spontaneous oscillatory field potentials as well as single-unit action potentials and allow to safely deliver electrical stimulation for evoking field potentials. The combined superior electrical properties, durability and 3D microstructure topology of the PEDOT-CNF composite electrodes demonstrate outstanding potential for developing future neural surface interfacing applications.Venkata Suresh VajralaValentin SaunierLionel G. NowakEmmanuel FlahautChristian BergaudAli MazizFrontiers Media S.A.articlePEDOT-Carboncarbon nanofibersporous compositeflexible neural interfaceselectrophysiological recordingneural stimulationBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PEDOT-Carbon carbon nanofibers porous composite flexible neural interfaces electrophysiological recording neural stimulation Biotechnology TP248.13-248.65
spellingShingle	PEDOT-Carbon carbon nanofibers porous composite flexible neural interfaces electrophysiological recording neural stimulation Biotechnology TP248.13-248.65 Venkata Suresh Vajrala Valentin Saunier Lionel G. Nowak Emmanuel Flahaut Christian Bergaud Ali Maziz Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
description	In this study, we report a flexible implantable 4-channel microelectrode probe coated with highly porous and robust nanocomposite of poly (3,4-ethylenedioxythiophene) (PEDOT) and carbon nanofiber (CNF) as a solid doping template for high-performance in vivo neuronal recording and stimulation. A simple yet well-controlled deposition strategy was developed via in situ electrochemical polymerization technique to create a porous network of PEDOT and CNFs on a flexible 4-channel gold microelectrode probe. Different morphological and electrochemical characterizations showed that they exhibit remarkable and superior electrochemical properties, yielding microelectrodes combining high surface area, low impedance (16.8 ± 2 MΩ µm2 at 1 kHz) and elevated charge injection capabilities (7.6 ± 1.3 mC/cm2) that exceed those of pure and composite PEDOT layers. In addition, the PEDOT-CNF composite electrode exhibited extended biphasic charge cycle endurance and excellent performance under accelerated lifetime testing, resulting in a negligible physical delamination and/or degradation for long periods of electrical stimulation. In vitro testing on mouse brain slices showed that they can record spontaneous oscillatory field potentials as well as single-unit action potentials and allow to safely deliver electrical stimulation for evoking field potentials. The combined superior electrical properties, durability and 3D microstructure topology of the PEDOT-CNF composite electrodes demonstrate outstanding potential for developing future neural surface interfacing applications.
format	article
author	Venkata Suresh Vajrala Valentin Saunier Lionel G. Nowak Emmanuel Flahaut Christian Bergaud Ali Maziz
author_facet	Venkata Suresh Vajrala Valentin Saunier Lionel G. Nowak Emmanuel Flahaut Christian Bergaud Ali Maziz
author_sort	Venkata Suresh Vajrala
title	Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
title_short	Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
title_full	Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
title_fullStr	Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
title_full_unstemmed	Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
title_sort	nanofibrous pedot-carbon composite on flexible probes for soft neural interfacing
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4782fd51761b4516b07546291a07c212
work_keys_str_mv	AT venkatasureshvajrala nanofibrouspedotcarboncompositeonflexibleprobesforsoftneuralinterfacing AT valentinsaunier nanofibrouspedotcarboncompositeonflexibleprobesforsoftneuralinterfacing AT lionelgnowak nanofibrouspedotcarboncompositeonflexibleprobesforsoftneuralinterfacing AT emmanuelflahaut nanofibrouspedotcarboncompositeonflexibleprobesforsoftneuralinterfacing AT christianbergaud nanofibrouspedotcarboncompositeonflexibleprobesforsoftneuralinterfacing AT alimaziz nanofibrouspedotcarboncompositeonflexibleprobesforsoftneuralinterfacing
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Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing

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