Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women

Abstract Background Research on psychosocial stress and risk of breast cancer has produced conflicting results. Few studies have assessed this relation by breast cancer subtype or specifically among Black women, who experience unique chronic stressors. Methods We used prospective data from the Black...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lauren E. Barber, Gary R. Zirpoli, Yvette C. Cozier, Lynn Rosenberg, Jessica L. Petrick, Kimberly A. Bertrand, Julie R. Palmer
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Breast cancer Disparities Socioeconomic Neighborhood Estrogen receptor negative breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4787cecc97a544108b0848736f913840
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4787cecc97a544108b0848736f913840
record_format	dspace
spelling	oai:doaj.org-article:4787cecc97a544108b0848736f9138402021-11-28T12:09:53ZNeighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women10.1186/s13058-021-01483-y1465-542Xhttps://doaj.org/article/4787cecc97a544108b0848736f9138402021-11-01T00:00:00Zhttps://doi.org/10.1186/s13058-021-01483-yhttps://doaj.org/toc/1465-542XAbstract Background Research on psychosocial stress and risk of breast cancer has produced conflicting results. Few studies have assessed this relation by breast cancer subtype or specifically among Black women, who experience unique chronic stressors. Methods We used prospective data from the Black Women’s Health Study, an ongoing cohort study of 59,000 US Black women, to assess neighborhood- and individual-level psychosocial factors in relation to risk of breast cancer. We used factor analysis to derive two neighborhood score variables after linking participant addresses to US Census data (2000 and 2010) on education, employment, income and poverty, female-headed households, and Black race for all households in each residential block group. We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for established breast cancer risk factors. Results During follow-up from 1995 to 2017, there were 2167 incident invasive breast cancer cases (1259 estrogen receptor positive (ER +); 687 ER negative (ER−)). For ER− breast cancer, HRs were 1.26 (95% CI 1.00–1.58) for women living in the highest quartile of neighborhood disadvantage relative to women in the lowest quartile, and 1.24 (95% CI 0.98–1.57) for lowest versus highest quartile of neighborhood socioeconomic status (SES). For ER+ breast cancer, living in the lowest quartile of neighborhood SES was associated with a reduced risk of ER+ breast cancer (HR = 0.83, 95% CI 0.70–0.98). With respect to individual-level factors, childhood sexual abuse (sexual assault ≥ 4 times vs. no abuse: HR = 1.35, 95% CI 1.01–1.79) and marital status (married/living together vs. single: HR = 1.29, 95% CI 1.08–1.53) were associated with higher risk of ER+, but not ER− breast cancer. Conclusion Neighborhood disadvantage and lower neighborhood SES were associated with an approximately 25% increased risk of ER− breast cancer in this large cohort of Black women, even after control for multiple behaviors and lifestyle factors. Further research is need to understand the underlying reasons for these associations. Possible contributing factors are biologic responses to the chronic stress/distress experienced by individuals who reside in neighborhoods characterized by high levels of noise, crime and unemployment or the direct effects of environmental toxins.Lauren E. BarberGary R. ZirpoliYvette C. CozierLynn RosenbergJessica L. PetrickKimberly A. BertrandJulie R. PalmerBMCarticleBreast cancerDisparitiesSocioeconomicNeighborhoodEstrogen receptor negative breast cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer Research, Vol 23, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer Disparities Socioeconomic Neighborhood Estrogen receptor negative breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast cancer Disparities Socioeconomic Neighborhood Estrogen receptor negative breast cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lauren E. Barber Gary R. Zirpoli Yvette C. Cozier Lynn Rosenberg Jessica L. Petrick Kimberly A. Bertrand Julie R. Palmer Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women
description	Abstract Background Research on psychosocial stress and risk of breast cancer has produced conflicting results. Few studies have assessed this relation by breast cancer subtype or specifically among Black women, who experience unique chronic stressors. Methods We used prospective data from the Black Women’s Health Study, an ongoing cohort study of 59,000 US Black women, to assess neighborhood- and individual-level psychosocial factors in relation to risk of breast cancer. We used factor analysis to derive two neighborhood score variables after linking participant addresses to US Census data (2000 and 2010) on education, employment, income and poverty, female-headed households, and Black race for all households in each residential block group. We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for established breast cancer risk factors. Results During follow-up from 1995 to 2017, there were 2167 incident invasive breast cancer cases (1259 estrogen receptor positive (ER +); 687 ER negative (ER−)). For ER− breast cancer, HRs were 1.26 (95% CI 1.00–1.58) for women living in the highest quartile of neighborhood disadvantage relative to women in the lowest quartile, and 1.24 (95% CI 0.98–1.57) for lowest versus highest quartile of neighborhood socioeconomic status (SES). For ER+ breast cancer, living in the lowest quartile of neighborhood SES was associated with a reduced risk of ER+ breast cancer (HR = 0.83, 95% CI 0.70–0.98). With respect to individual-level factors, childhood sexual abuse (sexual assault ≥ 4 times vs. no abuse: HR = 1.35, 95% CI 1.01–1.79) and marital status (married/living together vs. single: HR = 1.29, 95% CI 1.08–1.53) were associated with higher risk of ER+, but not ER− breast cancer. Conclusion Neighborhood disadvantage and lower neighborhood SES were associated with an approximately 25% increased risk of ER− breast cancer in this large cohort of Black women, even after control for multiple behaviors and lifestyle factors. Further research is need to understand the underlying reasons for these associations. Possible contributing factors are biologic responses to the chronic stress/distress experienced by individuals who reside in neighborhoods characterized by high levels of noise, crime and unemployment or the direct effects of environmental toxins.
format	article
author	Lauren E. Barber Gary R. Zirpoli Yvette C. Cozier Lynn Rosenberg Jessica L. Petrick Kimberly A. Bertrand Julie R. Palmer
author_facet	Lauren E. Barber Gary R. Zirpoli Yvette C. Cozier Lynn Rosenberg Jessica L. Petrick Kimberly A. Bertrand Julie R. Palmer
author_sort	Lauren E. Barber
title	Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women
title_short	Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women
title_full	Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women
title_fullStr	Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women
title_full_unstemmed	Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women
title_sort	neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in us black women
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4787cecc97a544108b0848736f913840
work_keys_str_mv	AT laurenebarber neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen AT garyrzirpoli neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen AT yvetteccozier neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen AT lynnrosenberg neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen AT jessicalpetrick neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen AT kimberlyabertrand neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen AT julierpalmer neighborhooddisadvantageandindividuallevellifestressorsinrelationtobreastcancerincidenceinusblackwomen
_version_	1718408136180629504

Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women

Ejemplares similares