Uterine perfusion in patients with MMP2 gene polymorphisms

Aim. To investigate the effect of allelic polymorphisms of the MMP2 gene on uterine perfusion in patients planning pregnancy. Materials and methods. 95 women planning pregnancy were examined. The patients underwent clinical and laboratory examination, analysis of single nucleotide polymorphisms r...

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Autores principales:	Tatiana E. Filipenkova, Liia N. Shcherbakova, Aleksandr V. Balatskiy, Larisa M. Samokhodskaya, Olga B. Panina
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	single nucleotide polymorphism haplotypes matrix metalloproteinase 2 doppler ultrasonography uterine artery Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/478b5b580c684fb2adb5e85cb1a2a5e8
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spelling	oai:doaj.org-article:478b5b580c684fb2adb5e85cb1a2a5e82021-12-02T19:22:24ZUterine perfusion in patients with MMP2 gene polymorphisms2079-56962079-583110.26442/20795696.2021.5.201056https://doaj.org/article/478b5b580c684fb2adb5e85cb1a2a5e82021-11-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/62568/pdfhttps://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To investigate the effect of allelic polymorphisms of the MMP2 gene on uterine perfusion in patients planning pregnancy. Materials and methods. 95 women planning pregnancy were examined. The patients underwent clinical and laboratory examination, analysis of single nucleotide polymorphisms rs2285052 and rs243865 of the MMP2 gene, ultrasound examination on days 1825 of the menstrual cycle with an assessment of the pulsatility index of blood flow of the uterine vessels and a qualitative assessment of endometrial and subendometrial perfusion. Depending on the genotype, the patients were divided into 3 groups: first with haplotype rs2285052(A)rs243865(T), second with haplotype rs2285052(A)rs243865(С), and a third control group with rs2285052(С/С)rs243865(С/С) genotype. Results. Decreased perfusion in the subendometrial zone was found in 40.6, 44.4 and 19.4% of patients in the 1, 2 and 3 groups, respectively; decreased perfusion of endometrium in 68.8, 55.6 and 36.1% of patients in the 1, 2 and 3 groups, respectively. Spiral arteries were not visualized in 28.1, 14.8 and 11.1% of patients in the 1, 2 and 3 groups, respectively. No statistical differences were found in the pulsatility index of uterine blood flow depending on the genotype. Conclusion. In patients with the A rs2285052 and T rs243865 alleles of the MMP2 gene poor vascular patterns of the endometrium and subendometrial zone of the uterus were statistically significantly more frequent, which can lead to infertility. These associations are more pronounced for the rs2285052 polymorphism. The simultaneous determination of the rs2285052 and rs243865 polymorphisms does not provide additional information compared to the definition of rs2285052 alone.Tatiana E. FilipenkovaLiia N. ShcherbakovaAleksandr V. BalatskiyLarisa M. SamokhodskayaOlga B. PaninaIP Berlin A.V. articlesingle nucleotide polymorphismhaplotypesmatrix metalloproteinase 2doppler ultrasonographyuterine arteryGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 5, Pp 413-420 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	single nucleotide polymorphism haplotypes matrix metalloproteinase 2 doppler ultrasonography uterine artery Gynecology and obstetrics RG1-991
spellingShingle	single nucleotide polymorphism haplotypes matrix metalloproteinase 2 doppler ultrasonography uterine artery Gynecology and obstetrics RG1-991 Tatiana E. Filipenkova Liia N. Shcherbakova Aleksandr V. Balatskiy Larisa M. Samokhodskaya Olga B. Panina Uterine perfusion in patients with MMP2 gene polymorphisms
description	Aim. To investigate the effect of allelic polymorphisms of the MMP2 gene on uterine perfusion in patients planning pregnancy. Materials and methods. 95 women planning pregnancy were examined. The patients underwent clinical and laboratory examination, analysis of single nucleotide polymorphisms rs2285052 and rs243865 of the MMP2 gene, ultrasound examination on days 1825 of the menstrual cycle with an assessment of the pulsatility index of blood flow of the uterine vessels and a qualitative assessment of endometrial and subendometrial perfusion. Depending on the genotype, the patients were divided into 3 groups: first with haplotype rs2285052(A)rs243865(T), second with haplotype rs2285052(A)rs243865(С), and a third control group with rs2285052(С/С)rs243865(С/С) genotype. Results. Decreased perfusion in the subendometrial zone was found in 40.6, 44.4 and 19.4% of patients in the 1, 2 and 3 groups, respectively; decreased perfusion of endometrium in 68.8, 55.6 and 36.1% of patients in the 1, 2 and 3 groups, respectively. Spiral arteries were not visualized in 28.1, 14.8 and 11.1% of patients in the 1, 2 and 3 groups, respectively. No statistical differences were found in the pulsatility index of uterine blood flow depending on the genotype. Conclusion. In patients with the A rs2285052 and T rs243865 alleles of the MMP2 gene poor vascular patterns of the endometrium and subendometrial zone of the uterus were statistically significantly more frequent, which can lead to infertility. These associations are more pronounced for the rs2285052 polymorphism. The simultaneous determination of the rs2285052 and rs243865 polymorphisms does not provide additional information compared to the definition of rs2285052 alone.
format	article
author	Tatiana E. Filipenkova Liia N. Shcherbakova Aleksandr V. Balatskiy Larisa M. Samokhodskaya Olga B. Panina
author_facet	Tatiana E. Filipenkova Liia N. Shcherbakova Aleksandr V. Balatskiy Larisa M. Samokhodskaya Olga B. Panina
author_sort	Tatiana E. Filipenkova
title	Uterine perfusion in patients with MMP2 gene polymorphisms
title_short	Uterine perfusion in patients with MMP2 gene polymorphisms
title_full	Uterine perfusion in patients with MMP2 gene polymorphisms
title_fullStr	Uterine perfusion in patients with MMP2 gene polymorphisms
title_full_unstemmed	Uterine perfusion in patients with MMP2 gene polymorphisms
title_sort	uterine perfusion in patients with mmp2 gene polymorphisms
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/478b5b580c684fb2adb5e85cb1a2a5e8
work_keys_str_mv	AT tatianaefilipenkova uterineperfusioninpatientswithmmp2genepolymorphisms AT liianshcherbakova uterineperfusioninpatientswithmmp2genepolymorphisms AT aleksandrvbalatskiy uterineperfusioninpatientswithmmp2genepolymorphisms AT larisamsamokhodskaya uterineperfusioninpatientswithmmp2genepolymorphisms AT olgabpanina uterineperfusioninpatientswithmmp2genepolymorphisms
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Uterine perfusion in patients with MMP2 gene polymorphisms

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