Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues

Activation<b> </b>of the tumor-associated stroma to support tumor growth is a common feature observed in different cancer entities. This principle is exemplified by cancer-associated fibroblasts (CAFs), which are educated by the tumor to shape its development across all stages. CAFs can...

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Autores principales:	Eiman Elwakeel, Andreas Weigert
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer-associated fibroblasts mammary carcinoma cancer tumor microenvironment extracellular matrix metastasis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/478de658c2c5455ca8ce2d6230488570
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spelling	oai:doaj.org-article:478de658c2c5455ca8ce2d62304885702021-11-11T17:06:40ZBreast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues10.3390/ijms2221116361422-00671661-6596https://doaj.org/article/478de658c2c5455ca8ce2d62304885702021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11636https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Activation<b> </b>of the tumor-associated stroma to support tumor growth is a common feature observed in different cancer entities. This principle is exemplified by cancer-associated fibroblasts (CAFs), which are educated by the tumor to shape its development across all stages. CAFs can alter the extracellular matrix (ECM) and secrete a variety of different molecules. In that manner they have the capability to affect activation, survival, proliferation, and migration of other stromal cells and cancer cell themselves. Alteration of the ECM, desmoplasia, is a common feature of breast cancer, indicating a prominent role for CAFs in shaping tumor development in the mammary gland. In this review, we summarize the multiple roles CAFs play in mammary carcinoma. We discuss experimental and clinical strategies to interfere with CAFs function in breast cancer. Moreover, we highlight the issues arising from CAFs heterogeneity and the need for further research to identify CAFs subpopulation(s) that can be targeted to improve breast cancer therapy.Eiman ElwakeelAndreas WeigertMDPI AGarticlecancer-associated fibroblastsmammary carcinomacancertumor microenvironmentextracellular matrixmetastasisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11636, p 11636 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer-associated fibroblasts mammary carcinoma cancer tumor microenvironment extracellular matrix metastasis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cancer-associated fibroblasts mammary carcinoma cancer tumor microenvironment extracellular matrix metastasis Biology (General) QH301-705.5 Chemistry QD1-999 Eiman Elwakeel Andreas Weigert Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
description	Activation<b> </b>of the tumor-associated stroma to support tumor growth is a common feature observed in different cancer entities. This principle is exemplified by cancer-associated fibroblasts (CAFs), which are educated by the tumor to shape its development across all stages. CAFs can alter the extracellular matrix (ECM) and secrete a variety of different molecules. In that manner they have the capability to affect activation, survival, proliferation, and migration of other stromal cells and cancer cell themselves. Alteration of the ECM, desmoplasia, is a common feature of breast cancer, indicating a prominent role for CAFs in shaping tumor development in the mammary gland. In this review, we summarize the multiple roles CAFs play in mammary carcinoma. We discuss experimental and clinical strategies to interfere with CAFs function in breast cancer. Moreover, we highlight the issues arising from CAFs heterogeneity and the need for further research to identify CAFs subpopulation(s) that can be targeted to improve breast cancer therapy.
format	article
author	Eiman Elwakeel Andreas Weigert
author_facet	Eiman Elwakeel Andreas Weigert
author_sort	Eiman Elwakeel
title	Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
title_short	Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
title_full	Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
title_fullStr	Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
title_full_unstemmed	Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
title_sort	breast cancer cafs: spectrum of phenotypes and promising targeting avenues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/478de658c2c5455ca8ce2d6230488570
work_keys_str_mv	AT eimanelwakeel breastcancercafsspectrumofphenotypesandpromisingtargetingavenues AT andreasweigert breastcancercafsspectrumofphenotypesandpromisingtargetingavenues
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Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues

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