The normal environment delays the development of multisensory integration

Abstract Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cros...

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Autores principales:	Jinghong Xu, Liping Yu, Benjamin A. Rowland, Barry E. Stein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47907b69b6ce49889fb12a883053bd1a
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spelling	oai:doaj.org-article:47907b69b6ce49889fb12a883053bd1a2021-12-02T11:40:21ZThe normal environment delays the development of multisensory integration10.1038/s41598-017-05118-12045-2322https://doaj.org/article/47907b69b6ce49889fb12a883053bd1a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05118-1https://doaj.org/toc/2045-2322Abstract Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cross-modal inputs. The present study demonstrates that superior colliculus (SC) neurons in animals whose visual-auditory experience is compromised early in life by noise-rearing can develop visual-auditory multisensory integration capabilities rapidly when periodically exposed to a single set of visual-auditory stimuli in a controlled laboratory paradigm. However, they remain compromised if their experiences are limited to a normal housing environment. These observations seem counterintuitive given that multisensory integrative capabilities ordinarily develop during early life in normal environments, in which a wide variety of sensory stimuli facilitate the functional organization of complex neural circuits at multiple levels of the neuraxis. However, the very richness and inherent variability of sensory stimuli in normal environments will lead to a less regular coupling of any given set of cross-modal cues than does the otherwise “impoverished” laboratory exposure paradigm. That this poses no significant problem for the neonate, but does for the adult, indicates a maturational shift in the requirements for the development of multisensory integration capabilities.Jinghong XuLiping YuBenjamin A. RowlandBarry E. SteinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinghong Xu Liping Yu Benjamin A. Rowland Barry E. Stein The normal environment delays the development of multisensory integration
description	Abstract Multisensory neurons in animals whose cross-modal experiences are compromised during early life fail to develop the ability to integrate information across those senses. Consequently, they lack the ability to increase the physiological salience of the events that provide the convergent cross-modal inputs. The present study demonstrates that superior colliculus (SC) neurons in animals whose visual-auditory experience is compromised early in life by noise-rearing can develop visual-auditory multisensory integration capabilities rapidly when periodically exposed to a single set of visual-auditory stimuli in a controlled laboratory paradigm. However, they remain compromised if their experiences are limited to a normal housing environment. These observations seem counterintuitive given that multisensory integrative capabilities ordinarily develop during early life in normal environments, in which a wide variety of sensory stimuli facilitate the functional organization of complex neural circuits at multiple levels of the neuraxis. However, the very richness and inherent variability of sensory stimuli in normal environments will lead to a less regular coupling of any given set of cross-modal cues than does the otherwise “impoverished” laboratory exposure paradigm. That this poses no significant problem for the neonate, but does for the adult, indicates a maturational shift in the requirements for the development of multisensory integration capabilities.
format	article
author	Jinghong Xu Liping Yu Benjamin A. Rowland Barry E. Stein
author_facet	Jinghong Xu Liping Yu Benjamin A. Rowland Barry E. Stein
author_sort	Jinghong Xu
title	The normal environment delays the development of multisensory integration
title_short	The normal environment delays the development of multisensory integration
title_full	The normal environment delays the development of multisensory integration
title_fullStr	The normal environment delays the development of multisensory integration
title_full_unstemmed	The normal environment delays the development of multisensory integration
title_sort	normal environment delays the development of multisensory integration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/47907b69b6ce49889fb12a883053bd1a
work_keys_str_mv	AT jinghongxu thenormalenvironmentdelaysthedevelopmentofmultisensoryintegration AT lipingyu thenormalenvironmentdelaysthedevelopmentofmultisensoryintegration AT benjaminarowland thenormalenvironmentdelaysthedevelopmentofmultisensoryintegration AT barryestein thenormalenvironmentdelaysthedevelopmentofmultisensoryintegration AT jinghongxu normalenvironmentdelaysthedevelopmentofmultisensoryintegration AT lipingyu normalenvironmentdelaysthedevelopmentofmultisensoryintegration AT benjaminarowland normalenvironmentdelaysthedevelopmentofmultisensoryintegration AT barryestein normalenvironmentdelaysthedevelopmentofmultisensoryintegration
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The normal environment delays the development of multisensory integration

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