High environmental ozone levels lead to enhanced allergenicity of birch pollen.

<h4>Background</h4>Evidence is compelling for a positive correlation between climate change, urbanisation and prevalence of allergic sensitisation and diseases. The reason for this association is not clear to date. Some data point to a pro-allergenic effect of anthropogenic factors on su...

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Autores principales:	Isabelle Beck, Susanne Jochner, Stefanie Gilles, Mareike McIntyre, Jeroen T M Buters, Carsten Schmidt-Weber, Heidrun Behrendt, Johannes Ring, Annette Menzel, Claudia Traidl-Hoffmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/479449dcb44f4f7d982531df4f6eba06
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spelling	oai:doaj.org-article:479449dcb44f4f7d982531df4f6eba062021-11-18T08:45:29ZHigh environmental ozone levels lead to enhanced allergenicity of birch pollen.1932-620310.1371/journal.pone.0080147https://doaj.org/article/479449dcb44f4f7d982531df4f6eba062013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278250/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Evidence is compelling for a positive correlation between climate change, urbanisation and prevalence of allergic sensitisation and diseases. The reason for this association is not clear to date. Some data point to a pro-allergenic effect of anthropogenic factors on susceptible individuals.<h4>Objectives</h4>To evaluate the impact of urbanisation and climate change on pollen allergenicity.<h4>Methods</h4>Catkins were sampled from birch trees from different sites across the greater area of Munich, pollen were isolated and an urbanisation index, NO2 and ozone exposure were determined. To estimate pollen allergenicity, allergen content and pollen-associated lipid mediators were measured in aqueous pollen extracts. Immune stimulatory and modulatory capacity of pollen was assessed by neutrophil migration assays and the potential of pollen to inhibit dendritic cell interleukin-12 response. In vivo allergenicity was assessed by skin prick tests.<h4>Results</h4>The study revealed ozone as a prominent environmental factor influencing the allergenicity of birch pollen. Enhanced allergenicity, as assessed in skin prick tests, was mirrored by enhanced allergen content. Beyond that, ozone induced changes in lipid composition and chemotactic and immune modulatory potential of the pollen. Higher ozone-exposed pollen was characterised by less immune modulatory but higher immune stimulatory potential.<h4>Conclusion</h4>It is likely that future climate change along with increasing urbanisation will lead to rising ozone concentrations in the next decades. Our study indicates that ozone is a crucial factor leading to clinically relevant enhanced allergenicity of birch pollen. Thus, with increasing temperatures and increasing ozone levels, also symptoms of pollen allergic patients may increase further.Isabelle BeckSusanne JochnerStefanie GillesMareike McIntyreJeroen T M ButersCarsten Schmidt-WeberHeidrun BehrendtJohannes RingAnnette MenzelClaudia Traidl-HoffmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80147 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle Beck Susanne Jochner Stefanie Gilles Mareike McIntyre Jeroen T M Buters Carsten Schmidt-Weber Heidrun Behrendt Johannes Ring Annette Menzel Claudia Traidl-Hoffmann High environmental ozone levels lead to enhanced allergenicity of birch pollen.
description	<h4>Background</h4>Evidence is compelling for a positive correlation between climate change, urbanisation and prevalence of allergic sensitisation and diseases. The reason for this association is not clear to date. Some data point to a pro-allergenic effect of anthropogenic factors on susceptible individuals.<h4>Objectives</h4>To evaluate the impact of urbanisation and climate change on pollen allergenicity.<h4>Methods</h4>Catkins were sampled from birch trees from different sites across the greater area of Munich, pollen were isolated and an urbanisation index, NO2 and ozone exposure were determined. To estimate pollen allergenicity, allergen content and pollen-associated lipid mediators were measured in aqueous pollen extracts. Immune stimulatory and modulatory capacity of pollen was assessed by neutrophil migration assays and the potential of pollen to inhibit dendritic cell interleukin-12 response. In vivo allergenicity was assessed by skin prick tests.<h4>Results</h4>The study revealed ozone as a prominent environmental factor influencing the allergenicity of birch pollen. Enhanced allergenicity, as assessed in skin prick tests, was mirrored by enhanced allergen content. Beyond that, ozone induced changes in lipid composition and chemotactic and immune modulatory potential of the pollen. Higher ozone-exposed pollen was characterised by less immune modulatory but higher immune stimulatory potential.<h4>Conclusion</h4>It is likely that future climate change along with increasing urbanisation will lead to rising ozone concentrations in the next decades. Our study indicates that ozone is a crucial factor leading to clinically relevant enhanced allergenicity of birch pollen. Thus, with increasing temperatures and increasing ozone levels, also symptoms of pollen allergic patients may increase further.
format	article
author	Isabelle Beck Susanne Jochner Stefanie Gilles Mareike McIntyre Jeroen T M Buters Carsten Schmidt-Weber Heidrun Behrendt Johannes Ring Annette Menzel Claudia Traidl-Hoffmann
author_facet	Isabelle Beck Susanne Jochner Stefanie Gilles Mareike McIntyre Jeroen T M Buters Carsten Schmidt-Weber Heidrun Behrendt Johannes Ring Annette Menzel Claudia Traidl-Hoffmann
author_sort	Isabelle Beck
title	High environmental ozone levels lead to enhanced allergenicity of birch pollen.
title_short	High environmental ozone levels lead to enhanced allergenicity of birch pollen.
title_full	High environmental ozone levels lead to enhanced allergenicity of birch pollen.
title_fullStr	High environmental ozone levels lead to enhanced allergenicity of birch pollen.
title_full_unstemmed	High environmental ozone levels lead to enhanced allergenicity of birch pollen.
title_sort	high environmental ozone levels lead to enhanced allergenicity of birch pollen.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/479449dcb44f4f7d982531df4f6eba06
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High environmental ozone levels lead to enhanced allergenicity of birch pollen.

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