T4SS-dependent TLR5 activation by Helicobacter pylori infection

T4SS-dependent TLR5 activation by Helicobacter pylori infection

Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like...

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Autores principales: Suneesh Kumar Pachathundikandi, Nicole Tegtmeyer, Isabelle Catherine Arnold, Judith Lind, Matthias Neddermann, Christina Falkeis-Veits, Sujay Chattopadhyay, Mark Brönstrup, Werner Tegge, Minsun Hong, Heinrich Sticht, Michael Vieth, Anne Müller, Steffen Backert
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4795a418a17340b78d3418bb043e2590
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spelling oai:doaj.org-article:4795a418a17340b78d3418bb043e25902021-12-02T15:36:19ZT4SS-dependent TLR5 activation by Helicobacter pylori infection10.1038/s41467-019-13506-62041-1723https://doaj.org/article/4795a418a17340b78d3418bb043e25902019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13506-6https://doaj.org/toc/2041-1723Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like motif.Suneesh Kumar PachathundikandiNicole TegtmeyerIsabelle Catherine ArnoldJudith LindMatthias NeddermannChristina Falkeis-VeitsSujay ChattopadhyayMark BrönstrupWerner TeggeMinsun HongHeinrich StichtMichael ViethAnne MüllerSteffen BackertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Suneesh Kumar Pachathundikandi
Nicole Tegtmeyer
Isabelle Catherine Arnold
Judith Lind
Matthias Neddermann
Christina Falkeis-Veits
Sujay Chattopadhyay
Mark Brönstrup
Werner Tegge
Minsun Hong
Heinrich Sticht
Michael Vieth
Anne Müller
Steffen Backert
T4SS-dependent TLR5 activation by Helicobacter pylori infection
description Toll-like receptor TLR5 recognizes a domain, D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Here, the authors show that TLR5 can be activated independently of flagellin by a component of the H. pylori type IV secretion system that contains a D1-like motif.
format article
author Suneesh Kumar Pachathundikandi
Nicole Tegtmeyer
Isabelle Catherine Arnold
Judith Lind
Matthias Neddermann
Christina Falkeis-Veits
Sujay Chattopadhyay
Mark Brönstrup
Werner Tegge
Minsun Hong
Heinrich Sticht
Michael Vieth
Anne Müller
Steffen Backert
author_facet Suneesh Kumar Pachathundikandi
Nicole Tegtmeyer
Isabelle Catherine Arnold
Judith Lind
Matthias Neddermann
Christina Falkeis-Veits
Sujay Chattopadhyay
Mark Brönstrup
Werner Tegge
Minsun Hong
Heinrich Sticht
Michael Vieth
Anne Müller
Steffen Backert
author_sort Suneesh Kumar Pachathundikandi
title T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_short T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_full T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_fullStr T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_full_unstemmed T4SS-dependent TLR5 activation by Helicobacter pylori infection
title_sort t4ss-dependent tlr5 activation by helicobacter pylori infection
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4795a418a17340b78d3418bb043e2590
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