Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2

Abstract Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype hete...

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Autores principales:	Surya Pavan Yenamandra, Carmen Koo, Suzanna Chiang, Han Shi Jeri Lim, Zhen Yuan Yeo, Lee Ching Ng, Hapuarachchige Chanditha Hapuarachchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4797decc89ab4b32a986e12a72597173
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spelling	oai:doaj.org-article:4797decc89ab4b32a986e12a725971732021-12-02T16:31:54ZEvolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 210.1038/s41598-021-92783-y2045-2322https://doaj.org/article/4797decc89ab4b32a986e12a725971732021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92783-yhttps://doaj.org/toc/2045-2322Abstract Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.Surya Pavan YenamandraCarmen KooSuzanna ChiangHan Shi Jeri LimZhen Yuan YeoLee Ching NgHapuarachchige Chanditha HapuarachchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Surya Pavan Yenamandra Carmen Koo Suzanna Chiang Han Shi Jeri Lim Zhen Yuan Yeo Lee Ching Ng Hapuarachchige Chanditha Hapuarachchi Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
description	Abstract Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.
format	article
author	Surya Pavan Yenamandra Carmen Koo Suzanna Chiang Han Shi Jeri Lim Zhen Yuan Yeo Lee Ching Ng Hapuarachchige Chanditha Hapuarachchi
author_facet	Surya Pavan Yenamandra Carmen Koo Suzanna Chiang Han Shi Jeri Lim Zhen Yuan Yeo Lee Ching Ng Hapuarachchige Chanditha Hapuarachchi
author_sort	Surya Pavan Yenamandra
title	Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
title_short	Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
title_full	Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
title_fullStr	Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
title_full_unstemmed	Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
title_sort	evolution, heterogeneity and global dispersal of cosmopolitan genotype of dengue virus type 2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4797decc89ab4b32a986e12a72597173
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Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2

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