No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations

Abstract Application of transcranial alternating current stimulation (tACS) is thought to modulate ongoing brain oscillations in a frequency-dependent manner. However, recent studies report various and sometimes inconsistent results regarding its capacity to induce changes in cortical activity beyon...

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Autores principales:	Louis-Philippe Lafleur, Audrey Murray, Manon Desforges, Kevin Pacheco-Barrios, Felipe Fregni, Sara Tremblay, Dave Saint-Amour, Jean-François Lepage, Hugo Théoret
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47984d810d744989bd90672f8acb1454
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spelling	oai:doaj.org-article:47984d810d744989bd90672f8acb14542021-11-08T10:54:06ZNo aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations10.1038/s41598-021-00850-12045-2322https://doaj.org/article/47984d810d744989bd90672f8acb14542021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00850-1https://doaj.org/toc/2045-2322Abstract Application of transcranial alternating current stimulation (tACS) is thought to modulate ongoing brain oscillations in a frequency-dependent manner. However, recent studies report various and sometimes inconsistent results regarding its capacity to induce changes in cortical activity beyond the stimulation period. Here, thirty healthy volunteers participated in a randomized, cross-over, sham-controlled, double-blind study using EEG to measure the offline effects of tACS on alpha and beta power. Sham and high current density tACS (1 mA; 10 Hz and 20 Hz; 0.32 mA/cm2) were applied for 20 min over bilateral sensorimotor areas and EEG was recorded at rest before and after stimulation for 20 min. Bilateral tACS was not associated with significant changes in local alpha and beta power frequencies at stimulation sites (C3 and C4 electrodes). Overall, the present results fail to provide evidence that bilateral tACS with high current density applied over sensorimotor regions at 10 and 20 Hz reliably modulates offline brain oscillation power at the stimulation site. These results may have implications for the design and implementation of future protocols aiming to induce sustained changes in brain activity, including in clinical populations.Louis-Philippe LafleurAudrey MurrayManon DesforgesKevin Pacheco-BarriosFelipe FregniSara TremblayDave Saint-AmourJean-François LepageHugo ThéoretNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Louis-Philippe Lafleur Audrey Murray Manon Desforges Kevin Pacheco-Barrios Felipe Fregni Sara Tremblay Dave Saint-Amour Jean-François Lepage Hugo Théoret No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations
description	Abstract Application of transcranial alternating current stimulation (tACS) is thought to modulate ongoing brain oscillations in a frequency-dependent manner. However, recent studies report various and sometimes inconsistent results regarding its capacity to induce changes in cortical activity beyond the stimulation period. Here, thirty healthy volunteers participated in a randomized, cross-over, sham-controlled, double-blind study using EEG to measure the offline effects of tACS on alpha and beta power. Sham and high current density tACS (1 mA; 10 Hz and 20 Hz; 0.32 mA/cm2) were applied for 20 min over bilateral sensorimotor areas and EEG was recorded at rest before and after stimulation for 20 min. Bilateral tACS was not associated with significant changes in local alpha and beta power frequencies at stimulation sites (C3 and C4 electrodes). Overall, the present results fail to provide evidence that bilateral tACS with high current density applied over sensorimotor regions at 10 and 20 Hz reliably modulates offline brain oscillation power at the stimulation site. These results may have implications for the design and implementation of future protocols aiming to induce sustained changes in brain activity, including in clinical populations.
format	article
author	Louis-Philippe Lafleur Audrey Murray Manon Desforges Kevin Pacheco-Barrios Felipe Fregni Sara Tremblay Dave Saint-Amour Jean-François Lepage Hugo Théoret
author_facet	Louis-Philippe Lafleur Audrey Murray Manon Desforges Kevin Pacheco-Barrios Felipe Fregni Sara Tremblay Dave Saint-Amour Jean-François Lepage Hugo Théoret
author_sort	Louis-Philippe Lafleur
title	No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations
title_short	No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations
title_full	No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations
title_fullStr	No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations
title_full_unstemmed	No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations
title_sort	no aftereffects of high current density 10 hz and 20 hz tacs on sensorimotor alpha and beta oscillations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47984d810d744989bd90672f8acb1454
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No aftereffects of high current density 10 Hz and 20 Hz tACS on sensorimotor alpha and beta oscillations

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