Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay....
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2012
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oai:doaj.org-article:4799e3f956364258a6743aa015a6bfc42021-11-18T08:04:58ZGraph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.1932-620310.1371/journal.pone.0050799https://doaj.org/article/4799e3f956364258a6743aa015a6bfc42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272072/?tool=EBIhttps://doaj.org/toc/1932-6203The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.Arantxa PalacínCristina Gómez-CasadoLuis A RivasJacobo AguirreLeticia TordesillasJoan BartraCarlos BlancoTeresa CarrilloJavier Cuesta-HerranzConsolación de FrutosGenoveva García Alvarez-EireFrancisco J FernándezPedro GamboaRosa MuñozRosa Sánchez-MongeSofía SirventMaría J TorresSusana Varela-LosadaRosalía RodríguezVictor ParroMiguel BlancaGabriel SalcedoAraceli Díaz-PeralesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e50799 (2012) |
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Medicine R Science Q Arantxa Palacín Cristina Gómez-Casado Luis A Rivas Jacobo Aguirre Leticia Tordesillas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Alvarez-Eire Francisco J Fernández Pedro Gamboa Rosa Muñoz Rosa Sánchez-Monge Sofía Sirvent María J Torres Susana Varela-Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Araceli Díaz-Perales Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| description |
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens. |
| format |
article |
| author |
Arantxa Palacín Cristina Gómez-Casado Luis A Rivas Jacobo Aguirre Leticia Tordesillas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Alvarez-Eire Francisco J Fernández Pedro Gamboa Rosa Muñoz Rosa Sánchez-Monge Sofía Sirvent María J Torres Susana Varela-Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Araceli Díaz-Perales |
| author_facet |
Arantxa Palacín Cristina Gómez-Casado Luis A Rivas Jacobo Aguirre Leticia Tordesillas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Alvarez-Eire Francisco J Fernández Pedro Gamboa Rosa Muñoz Rosa Sánchez-Monge Sofía Sirvent María J Torres Susana Varela-Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Araceli Díaz-Perales |
| author_sort |
Arantxa Palacín |
| title |
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_short |
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_full |
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_fullStr |
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_full_unstemmed |
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. |
| title_sort |
graph based study of allergen cross-reactivity of plant lipid transfer proteins (ltps) using microarray in a multicenter study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/4799e3f956364258a6743aa015a6bfc4 |
| work_keys_str_mv |
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