PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY

Abstract. The work deals with quantitative methods developed for estimation of nuclease and proteolytic activities of autoantibodies. By means of these techniques, appropriate catalytic activities of abzyme-type antibodies were studied in patients with diabetes mellitus type 1, and in su...

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Autores principales:	L. N. Luchverchyk, N. V. Piven, A. I. Burakovsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoimmune disorders diabetes mellitus autoimmune thyroiditis abzyme-type autoantibodies catalytic activity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/479b978e17d6476fa5514b037a0965a8
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spelling	oai:doaj.org-article:479b978e17d6476fa5514b037a0965a82021-11-18T08:03:42ZPATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY1563-06252313-741X10.15789/1563-0625-2011-2-3-145-150https://doaj.org/article/479b978e17d6476fa5514b037a0965a82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/491https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The work deals with quantitative methods developed for estimation of nuclease and proteolytic activities of autoantibodies. By means of these techniques, appropriate catalytic activities of abzyme-type antibodies were studied in patients with diabetes mellitus type 1, and in subjects with autoimmune thyroiditis. Oppositely directed changes of the mentioned catalytic activities have been found for autoantibodies of different specificity. Autoantibodies occurring in autoimmune thyroiditis showed an increase of both nuclease and proteolytic activities. Meanwhile, the autoantibodies in diabetes mellitus had increased nuclease activity, along with decreased proteolytic activity. These findings are suggestive for existence of two pathogenetic mechanisms in organ-specific autoimmune pathology that are associated either with direct involvement of Fab fragments of auto-antibodies in autoimmune destruction, or with complement-dependent lysis mediated by Fc-fragments and cytotoxic destruction of target cells by cytotoxic T-lymphocytes. The unique site-specific catalytic autoantibodies were established to exert a selective destructive effect upon target cells, thus making a major contribution to the antibody-dependent mechanisms of cytotoxicity in autoimmune diseases. (Med. Immunol., 2011, vol. 13, N 2-3, pp 145-150)L. N. LuchverchykN. V. PivenA. I. BurakovskySPb RAACIarticleautoimmune disordersdiabetes mellitusautoimmune thyroiditisabzyme-type autoantibodiescatalytic activityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 145-150 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmune disorders diabetes mellitus autoimmune thyroiditis abzyme-type autoantibodies catalytic activity Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmune disorders diabetes mellitus autoimmune thyroiditis abzyme-type autoantibodies catalytic activity Immunologic diseases. Allergy RC581-607 L. N. Luchverchyk N. V. Piven A. I. Burakovsky PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
description	Abstract. The work deals with quantitative methods developed for estimation of nuclease and proteolytic activities of autoantibodies. By means of these techniques, appropriate catalytic activities of abzyme-type antibodies were studied in patients with diabetes mellitus type 1, and in subjects with autoimmune thyroiditis. Oppositely directed changes of the mentioned catalytic activities have been found for autoantibodies of different specificity. Autoantibodies occurring in autoimmune thyroiditis showed an increase of both nuclease and proteolytic activities. Meanwhile, the autoantibodies in diabetes mellitus had increased nuclease activity, along with decreased proteolytic activity. These findings are suggestive for existence of two pathogenetic mechanisms in organ-specific autoimmune pathology that are associated either with direct involvement of Fab fragments of auto-antibodies in autoimmune destruction, or with complement-dependent lysis mediated by Fc-fragments and cytotoxic destruction of target cells by cytotoxic T-lymphocytes. The unique site-specific catalytic autoantibodies were established to exert a selective destructive effect upon target cells, thus making a major contribution to the antibody-dependent mechanisms of cytotoxicity in autoimmune diseases. (Med. Immunol., 2011, vol. 13, N 2-3, pp 145-150)
format	article
author	L. N. Luchverchyk N. V. Piven A. I. Burakovsky
author_facet	L. N. Luchverchyk N. V. Piven A. I. Burakovsky
author_sort	L. N. Luchverchyk
title	PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
title_short	PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
title_full	PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
title_fullStr	PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
title_full_unstemmed	PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
title_sort	pathogenetic role of abzyme-type autoantibodies in the organ-specific autoimmune pathology
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/479b978e17d6476fa5514b037a0965a8
work_keys_str_mv	AT lnluchverchyk pathogeneticroleofabzymetypeautoantibodiesintheorganspecificautoimmunepathology AT nvpiven pathogeneticroleofabzymetypeautoantibodiesintheorganspecificautoimmunepathology AT aiburakovsky pathogeneticroleofabzymetypeautoantibodiesintheorganspecificautoimmunepathology
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PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY

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