Deciphering the state of immune silence in fatal COVID-19 patients

Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencing of blood and matched BAL cells with deep clinica...

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Autores principales:	Pierre Bost, Francesco De Sanctis, Stefania Canè, Stefano Ugel, Katia Donadello, Monica Castellucci, David Eyal, Alessandra Fiore, Cristina Anselmi, Roza Maria Barouni, Rosalinda Trovato, Simone Caligola, Alessia Lamolinara, Manuela Iezzi, Federica Facciotti, Annarita Mazzariol, Davide Gibellini, Pasquale De Nardo, Evelina Tacconelli, Leonardo Gottin, Enrico Polati, Benno Schwikowski, Ido Amit, Vincenzo Bronte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/479c40aff76e43fcad6b8bae647af648
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spelling	oai:doaj.org-article:479c40aff76e43fcad6b8bae647af6482021-12-02T13:14:53ZDeciphering the state of immune silence in fatal COVID-19 patients10.1038/s41467-021-21702-62041-1723https://doaj.org/article/479c40aff76e43fcad6b8bae647af6482021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21702-6https://doaj.org/toc/2041-1723Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencing of blood and matched BAL cells with deep clinical, immunological and functional data.Pierre BostFrancesco De SanctisStefania CanèStefano UgelKatia DonadelloMonica CastellucciDavid EyalAlessandra FioreCristina AnselmiRoza Maria BarouniRosalinda TrovatoSimone CaligolaAlessia LamolinaraManuela IezziFederica FacciottiAnnarita MazzariolDavide GibelliniPasquale De NardoEvelina TacconelliLeonardo GottinEnrico PolatiBenno SchwikowskiIdo AmitVincenzo BronteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Bost Francesco De Sanctis Stefania Canè Stefano Ugel Katia Donadello Monica Castellucci David Eyal Alessandra Fiore Cristina Anselmi Roza Maria Barouni Rosalinda Trovato Simone Caligola Alessia Lamolinara Manuela Iezzi Federica Facciotti Annarita Mazzariol Davide Gibellini Pasquale De Nardo Evelina Tacconelli Leonardo Gottin Enrico Polati Benno Schwikowski Ido Amit Vincenzo Bronte Deciphering the state of immune silence in fatal COVID-19 patients
description	Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencing of blood and matched BAL cells with deep clinical, immunological and functional data.
format	article
author	Pierre Bost Francesco De Sanctis Stefania Canè Stefano Ugel Katia Donadello Monica Castellucci David Eyal Alessandra Fiore Cristina Anselmi Roza Maria Barouni Rosalinda Trovato Simone Caligola Alessia Lamolinara Manuela Iezzi Federica Facciotti Annarita Mazzariol Davide Gibellini Pasquale De Nardo Evelina Tacconelli Leonardo Gottin Enrico Polati Benno Schwikowski Ido Amit Vincenzo Bronte
author_facet	Pierre Bost Francesco De Sanctis Stefania Canè Stefano Ugel Katia Donadello Monica Castellucci David Eyal Alessandra Fiore Cristina Anselmi Roza Maria Barouni Rosalinda Trovato Simone Caligola Alessia Lamolinara Manuela Iezzi Federica Facciotti Annarita Mazzariol Davide Gibellini Pasquale De Nardo Evelina Tacconelli Leonardo Gottin Enrico Polati Benno Schwikowski Ido Amit Vincenzo Bronte
author_sort	Pierre Bost
title	Deciphering the state of immune silence in fatal COVID-19 patients
title_short	Deciphering the state of immune silence in fatal COVID-19 patients
title_full	Deciphering the state of immune silence in fatal COVID-19 patients
title_fullStr	Deciphering the state of immune silence in fatal COVID-19 patients
title_full_unstemmed	Deciphering the state of immune silence in fatal COVID-19 patients
title_sort	deciphering the state of immune silence in fatal covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/479c40aff76e43fcad6b8bae647af648
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Deciphering the state of immune silence in fatal COVID-19 patients

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