Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis

Abstract Mannan-binding lectin-associated serine protease-2 (MASP-2) has been reported to play an important role as a key enzyme in the lectin pathway of the complement system. The objectives of our study were to determine whether the single-nucleotide polymorphism (SNPs) of MASP2 and the gene-tea d...

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Autores principales:	Zihao Li, Mian Wang, Hua Zhong, Xin Huang, Xinyin Wu, Xian Zhang, Jing Wang, Jing Deng, Mengshi Chen, Lizhang Chen, Hongzhuan Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/479d0b44a5b644f6a63ffceea253dbce
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spelling	oai:doaj.org-article:479d0b44a5b644f6a63ffceea253dbce2021-12-02T11:45:04ZImpact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis10.1038/s41598-021-86129-x2045-2322https://doaj.org/article/479d0b44a5b644f6a63ffceea253dbce2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86129-xhttps://doaj.org/toc/2045-2322Abstract Mannan-binding lectin-associated serine protease-2 (MASP-2) has been reported to play an important role as a key enzyme in the lectin pathway of the complement system. The objectives of our study were to determine whether the single-nucleotide polymorphism (SNPs) of MASP2 and the gene-tea drinking interaction were associated with the susceptibility to TB. In total, 503 patients and 494 healthy controls were contained. Three SNPs (rs12142107, rs12711521, and rs7548659) were genotyped. The association between the SNPs and susceptibility to TB were investigated by conducting multivariate unconditional logistic regression analysis. The gene-tea drinking interactions were analyzed by the additive model of marginal structural linear odds models. Both genotype AC + AA at rs12711521 of MASP2 genes and genotype GT + GG at rs7548659 of MASP2 genes were more prevalent in the TB patient group than the healthy control group (OR: 1.423 and 1.439, respectively, P < 0.05). In addition, The relative excess risk of interaction (RERI) between tea drinking and rs12142107, rs12711521, and rs7548659 of MASP2 genes was found to suggest negative interactions, which reached − 0.2311 (95% confidence interval (CI): − 0.4736, − 0.0113), − 0.7080 (95% CI − 1.3998, − 0.0163), and − 0.5140 (95% CI − 0.8988, − 0.1291), respectively (P < 0.05). Our finding indicated that the SNPs (rs12711521 and rs7548659) of MASP2 were associated with the susceptibility to TB. Furthermore, there were negative interactions between tea drinking and rs12142107, rs12711521, and rs75548659 of MASP2 gene, respectively. Our research provides a basis for studying the pathogenesis and prevention of tuberculosis.Zihao LiMian WangHua ZhongXin HuangXinyin WuXian ZhangJing WangJing DengMengshi ChenLizhang ChenHongzhuan TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zihao Li Mian Wang Hua Zhong Xin Huang Xinyin Wu Xian Zhang Jing Wang Jing Deng Mengshi Chen Lizhang Chen Hongzhuan Tan Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
description	Abstract Mannan-binding lectin-associated serine protease-2 (MASP-2) has been reported to play an important role as a key enzyme in the lectin pathway of the complement system. The objectives of our study were to determine whether the single-nucleotide polymorphism (SNPs) of MASP2 and the gene-tea drinking interaction were associated with the susceptibility to TB. In total, 503 patients and 494 healthy controls were contained. Three SNPs (rs12142107, rs12711521, and rs7548659) were genotyped. The association between the SNPs and susceptibility to TB were investigated by conducting multivariate unconditional logistic regression analysis. The gene-tea drinking interactions were analyzed by the additive model of marginal structural linear odds models. Both genotype AC + AA at rs12711521 of MASP2 genes and genotype GT + GG at rs7548659 of MASP2 genes were more prevalent in the TB patient group than the healthy control group (OR: 1.423 and 1.439, respectively, P < 0.05). In addition, The relative excess risk of interaction (RERI) between tea drinking and rs12142107, rs12711521, and rs7548659 of MASP2 genes was found to suggest negative interactions, which reached − 0.2311 (95% confidence interval (CI): − 0.4736, − 0.0113), − 0.7080 (95% CI − 1.3998, − 0.0163), and − 0.5140 (95% CI − 0.8988, − 0.1291), respectively (P < 0.05). Our finding indicated that the SNPs (rs12711521 and rs7548659) of MASP2 were associated with the susceptibility to TB. Furthermore, there were negative interactions between tea drinking and rs12142107, rs12711521, and rs75548659 of MASP2 gene, respectively. Our research provides a basis for studying the pathogenesis and prevention of tuberculosis.
format	article
author	Zihao Li Mian Wang Hua Zhong Xin Huang Xinyin Wu Xian Zhang Jing Wang Jing Deng Mengshi Chen Lizhang Chen Hongzhuan Tan
author_facet	Zihao Li Mian Wang Hua Zhong Xin Huang Xinyin Wu Xian Zhang Jing Wang Jing Deng Mengshi Chen Lizhang Chen Hongzhuan Tan
author_sort	Zihao Li
title	Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
title_short	Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
title_full	Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
title_fullStr	Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
title_full_unstemmed	Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
title_sort	impact of masp2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/479d0b44a5b644f6a63ffceea253dbce
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Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis

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