Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion

<h4>Aims</h4> Insulin sensitivity and insulin secretion can be estimated by multiple indices from fasting blood samples or blood samples obtained during oral glucose tolerance tests. The test-retest reliability of these indices in repeated measurements within the same individuals can str...

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Autores principales:	Sarah Hudak, Philipp Huber, Apostolia Lamprinou, Louise Fritsche, Norbert Stefan, Andreas Peter, Andreas L. Birkenfeld, Andreas Fritsche, Martin Heni, Robert Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47a215a57a594f7586ce3b92219f49f3
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spelling	oai:doaj.org-article:47a215a57a594f7586ce3b92219f49f32021-11-04T06:19:41ZReproducibility and discrimination of different indices of insulin sensitivity and insulin secretion1932-6203https://doaj.org/article/47a215a57a594f7586ce3b92219f49f32021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549015/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4> Insulin sensitivity and insulin secretion can be estimated by multiple indices from fasting blood samples or blood samples obtained during oral glucose tolerance tests. The test-retest reliability of these indices in repeated measurements within the same individuals can strongly vary. <h4>Methods</h4> We analyzed data of persons without diabetes who underwent two repeated OGTTs. For each measurement pair, we calculated multiple commonly used indices for the assessment of insulin secretion and insulin sensitivity. We then evaluated the coefficient of variation (standard deviation/mean) and discriminant ratio for each index. <h4>Results</h4> 89 persons underwent two OGTTs with a median interval of 86 days (IQR 64–249). Among indices of insulin sensitivity derived from fasting blood samples, the revised quantitative insulin sensitivity check index had the smallest coefficient of variation (2.8 ± 2.1%) whereas the C-peptide based homeostasis model assessment 2 had the highest discriminant ratio (1.97 (1.65–2.39)). As for insulin sensitivity indices that are based on OGTT, the oral glucose insulin sensitivity index had the smallest coefficient of variation (6.5 ± 5.1%). The highest discriminant ratio was found for the non-esterified fatty acids-based insulin sensitivity index (NEFA-ISI, 2.70 (2.30–3.22)). For the assessment of insulin secretion from fasting variables, the lowest mean coefficient of variation was found for C-peptide based homeostasis model assessment 2 beta with 10.8 ± 8% and the highest discriminant ratio for the C-peptide / Glucose-Ratio (2.18 (1.84–2.63)). Among indices assessing insulin secretion from an OGTT, the lowest coefficient of variation was found for the ratio of the areas under the C-peptide and glucose curves from 0 to 120 minutes with 11.3 ± 9.7%. <h4>Conclusion</h4> The data reveal large differences in the reproducibility and the discrimination capability of different indices that assess insulin sensitivity or insulin secretion. Our findings can aid the selection of an appropriate index in clinical studies.Sarah HudakPhilipp HuberApostolia LamprinouLouise FritscheNorbert StefanAndreas PeterAndreas L. BirkenfeldAndreas FritscheMartin HeniRobert WagnerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah Hudak Philipp Huber Apostolia Lamprinou Louise Fritsche Norbert Stefan Andreas Peter Andreas L. Birkenfeld Andreas Fritsche Martin Heni Robert Wagner Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
description	<h4>Aims</h4> Insulin sensitivity and insulin secretion can be estimated by multiple indices from fasting blood samples or blood samples obtained during oral glucose tolerance tests. The test-retest reliability of these indices in repeated measurements within the same individuals can strongly vary. <h4>Methods</h4> We analyzed data of persons without diabetes who underwent two repeated OGTTs. For each measurement pair, we calculated multiple commonly used indices for the assessment of insulin secretion and insulin sensitivity. We then evaluated the coefficient of variation (standard deviation/mean) and discriminant ratio for each index. <h4>Results</h4> 89 persons underwent two OGTTs with a median interval of 86 days (IQR 64–249). Among indices of insulin sensitivity derived from fasting blood samples, the revised quantitative insulin sensitivity check index had the smallest coefficient of variation (2.8 ± 2.1%) whereas the C-peptide based homeostasis model assessment 2 had the highest discriminant ratio (1.97 (1.65–2.39)). As for insulin sensitivity indices that are based on OGTT, the oral glucose insulin sensitivity index had the smallest coefficient of variation (6.5 ± 5.1%). The highest discriminant ratio was found for the non-esterified fatty acids-based insulin sensitivity index (NEFA-ISI, 2.70 (2.30–3.22)). For the assessment of insulin secretion from fasting variables, the lowest mean coefficient of variation was found for C-peptide based homeostasis model assessment 2 beta with 10.8 ± 8% and the highest discriminant ratio for the C-peptide / Glucose-Ratio (2.18 (1.84–2.63)). Among indices assessing insulin secretion from an OGTT, the lowest coefficient of variation was found for the ratio of the areas under the C-peptide and glucose curves from 0 to 120 minutes with 11.3 ± 9.7%. <h4>Conclusion</h4> The data reveal large differences in the reproducibility and the discrimination capability of different indices that assess insulin sensitivity or insulin secretion. Our findings can aid the selection of an appropriate index in clinical studies.
format	article
author	Sarah Hudak Philipp Huber Apostolia Lamprinou Louise Fritsche Norbert Stefan Andreas Peter Andreas L. Birkenfeld Andreas Fritsche Martin Heni Robert Wagner
author_facet	Sarah Hudak Philipp Huber Apostolia Lamprinou Louise Fritsche Norbert Stefan Andreas Peter Andreas L. Birkenfeld Andreas Fritsche Martin Heni Robert Wagner
author_sort	Sarah Hudak
title	Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
title_short	Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
title_full	Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
title_fullStr	Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
title_full_unstemmed	Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
title_sort	reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/47a215a57a594f7586ce3b92219f49f3
work_keys_str_mv	AT sarahhudak reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT philipphuber reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT apostolialamprinou reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT louisefritsche reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT norbertstefan reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT andreaspeter reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT andreaslbirkenfeld reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT andreasfritsche reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT martinheni reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion AT robertwagner reproducibilityanddiscriminationofdifferentindicesofinsulinsensitivityandinsulinsecretion
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Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion

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