Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.

<h4>Purpose</h4>To ascertain whether the incidence of ocular dicrotic pulse (ODP) increases with age, it is more pronounced in glaucomatous than in normal eyes and whether it is related to cardiovascular activity.<h4>Methods</h4>261 subjects aged 47 to 78 years were included...

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Autores principales:	Monika E Danielewska, Patrycja Krzyżanowska-Berkowska, D Robert Iskander
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47a50db7dd2046fdb97564440f12827e
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spelling	oai:doaj.org-article:47a50db7dd2046fdb97564440f12827e2021-11-25T06:08:10ZGlaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.1932-620310.1371/journal.pone.0102814https://doaj.org/article/47a50db7dd2046fdb97564440f12827e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25032962/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To ascertain whether the incidence of ocular dicrotic pulse (ODP) increases with age, it is more pronounced in glaucomatous than in normal eyes and whether it is related to cardiovascular activity.<h4>Methods</h4>261 subjects aged 47 to 78 years were included in the study and classified into four groups: primary open angle glaucoma (POAG), primary angle-closure glaucoma (PACG), glaucoma suspects with glaucomatous optic disc appearance (GODA) and the controls (CG). Additionally, in each group, subjects with ODP were divided into two age subgroups around the median age. A non-contact ultrasonic method was used to measure corneal indentation pulse (CIP) synchronically with the acquisition of electrocardiography (ECG) and blood pulse signals. ODP was assessed from the acquired signals that were numerically processed in a custom written program.<h4>Results</h4>ODP incidence was about 78%, 66%, 66% and 84% for CG, GODA, POAG, and PACG group, respectively. With advancing age, the ODP incidence increased for all subjects (Δ = 12%), the highest being for the PACG and POAG groups (Δ = 30%). GODA group did not show an age-related increase in the incidence of ODP.<h4>Conclusions</h4>The ocular dicrotism, measured with non-contact ultrasonic method, was found to be a common phenomenon in elderly subjects. The increased ODP incidence in PACG and POAG group may correspond to either higher stiffness of glaucoma eyes, biochemical abnormalities in eye tissues, changes in ocular hemodynamics, may reflect the effect of medications or be a combination of all those factors. The results of GODA group suggest different mechanisms governing their ocular pulse that makes them less susceptible to generating ODP and having decreased predisposition to glaucoma.Monika E DanielewskaPatrycja Krzyżanowska-BerkowskaD Robert IskanderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102814 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monika E Danielewska Patrycja Krzyżanowska-Berkowska D Robert Iskander Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.
description	<h4>Purpose</h4>To ascertain whether the incidence of ocular dicrotic pulse (ODP) increases with age, it is more pronounced in glaucomatous than in normal eyes and whether it is related to cardiovascular activity.<h4>Methods</h4>261 subjects aged 47 to 78 years were included in the study and classified into four groups: primary open angle glaucoma (POAG), primary angle-closure glaucoma (PACG), glaucoma suspects with glaucomatous optic disc appearance (GODA) and the controls (CG). Additionally, in each group, subjects with ODP were divided into two age subgroups around the median age. A non-contact ultrasonic method was used to measure corneal indentation pulse (CIP) synchronically with the acquisition of electrocardiography (ECG) and blood pulse signals. ODP was assessed from the acquired signals that were numerically processed in a custom written program.<h4>Results</h4>ODP incidence was about 78%, 66%, 66% and 84% for CG, GODA, POAG, and PACG group, respectively. With advancing age, the ODP incidence increased for all subjects (Δ = 12%), the highest being for the PACG and POAG groups (Δ = 30%). GODA group did not show an age-related increase in the incidence of ODP.<h4>Conclusions</h4>The ocular dicrotism, measured with non-contact ultrasonic method, was found to be a common phenomenon in elderly subjects. The increased ODP incidence in PACG and POAG group may correspond to either higher stiffness of glaucoma eyes, biochemical abnormalities in eye tissues, changes in ocular hemodynamics, may reflect the effect of medications or be a combination of all those factors. The results of GODA group suggest different mechanisms governing their ocular pulse that makes them less susceptible to generating ODP and having decreased predisposition to glaucoma.
format	article
author	Monika E Danielewska Patrycja Krzyżanowska-Berkowska D Robert Iskander
author_facet	Monika E Danielewska Patrycja Krzyżanowska-Berkowska D Robert Iskander
author_sort	Monika E Danielewska
title	Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.
title_short	Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.
title_full	Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.
title_fullStr	Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.
title_full_unstemmed	Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.
title_sort	glaucomatous and age-related changes in corneal pulsation shape. the ocular dicrotism.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/47a50db7dd2046fdb97564440f12827e
work_keys_str_mv	AT monikaedanielewska glaucomatousandagerelatedchangesincornealpulsationshapetheoculardicrotism AT patrycjakrzyzanowskaberkowska glaucomatousandagerelatedchangesincornealpulsationshapetheoculardicrotism AT drobertiskander glaucomatousandagerelatedchangesincornealpulsationshapetheoculardicrotism
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Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism.

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