Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

Abstract Genomic instability represents a typical feature of aggressive cancers. Normal cells have evolved intricate responses to preserve genomic integrity in response to stress, such as DNA damage induced by γ-irradiation. Cyclin-dependent kinases (CDKs) take crucial part to these safeguard mechan...

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Autores principales: Stefania Berton, Martina Cusan, Ilenia Segatto, Francesca Citron, Sara D’Andrea, Sara Benevol, Michele Avanzo, Alessandra Dall’Acqua, Monica Schiappacassi, Robert G. Bristow, Barbara Belletti, Gustavo Baldassarre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/47a79c5a3bde4c8fbdb773c1e4abc039
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