Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

Abstract Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resu...

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Autores principales:	Carmen P. Wong, Urszula T. Iwaniec, Russell T. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/47a7f24b1d634c50818302d512570895
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spelling	oai:doaj.org-article:47a7f24b1d634c50818302d5125708952021-12-02T17:40:43ZEvidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station10.1038/s41526-021-00150-y2373-8065https://doaj.org/article/47a7f24b1d634c50818302d5125708952021-06-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00150-yhttps://doaj.org/toc/2373-8065Abstract Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.Carmen P. WongUrszula T. IwaniecRussell T. TurnerNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Carmen P. Wong Urszula T. Iwaniec Russell T. Turner Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
description	Abstract Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.
format	article
author	Carmen P. Wong Urszula T. Iwaniec Russell T. Turner
author_facet	Carmen P. Wong Urszula T. Iwaniec Russell T. Turner
author_sort	Carmen P. Wong
title	Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_short	Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_full	Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_fullStr	Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_full_unstemmed	Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_sort	evidence for increased thermogenesis in female c57bl/6j mice housed aboard the international space station
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47a7f24b1d634c50818302d512570895
work_keys_str_mv	AT carmenpwong evidenceforincreasedthermogenesisinfemalec57bl6jmicehousedaboardtheinternationalspacestation AT urszulatiwaniec evidenceforincreasedthermogenesisinfemalec57bl6jmicehousedaboardtheinternationalspacestation AT russelltturner evidenceforincreasedthermogenesisinfemalec57bl6jmicehousedaboardtheinternationalspacestation
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Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

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