Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII

The connection between metal binding to proteins and availabilities of different metals in cells has been unclear. Here, the authors report a metalation-calculator that takes into account competition between metals and their variable accessibility, and thereby elucidate in vivo metal occupancies of...

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Autores principales:	Tessa R. Young, Maria Alessandra Martini, Andrew W. Foster, Arthur Glasfeld, Deenah Osman, Richard J. Morton, Evelyne Deery, Martin J. Warren, Nigel J. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47a874e4fffe4f87807b18d00ce0daa2
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spelling	oai:doaj.org-article:47a874e4fffe4f87807b18d00ce0daa22021-12-02T12:11:39ZCalculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII10.1038/s41467-021-21479-82041-1723https://doaj.org/article/47a874e4fffe4f87807b18d00ce0daa22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21479-8https://doaj.org/toc/2041-1723The connection between metal binding to proteins and availabilities of different metals in cells has been unclear. Here, the authors report a metalation-calculator that takes into account competition between metals and their variable accessibility, and thereby elucidate in vivo metal occupancies of three different proteins, CobW, YeiR and YjiA.Tessa R. YoungMaria Alessandra MartiniAndrew W. FosterArthur GlasfeldDeenah OsmanRichard J. MortonEvelyne DeeryMartin J. WarrenNigel J. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tessa R. Young Maria Alessandra Martini Andrew W. Foster Arthur Glasfeld Deenah Osman Richard J. Morton Evelyne Deery Martin J. Warren Nigel J. Robinson Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
description	The connection between metal binding to proteins and availabilities of different metals in cells has been unclear. Here, the authors report a metalation-calculator that takes into account competition between metals and their variable accessibility, and thereby elucidate in vivo metal occupancies of three different proteins, CobW, YeiR and YjiA.
format	article
author	Tessa R. Young Maria Alessandra Martini Andrew W. Foster Arthur Glasfeld Deenah Osman Richard J. Morton Evelyne Deery Martin J. Warren Nigel J. Robinson
author_facet	Tessa R. Young Maria Alessandra Martini Andrew W. Foster Arthur Glasfeld Deenah Osman Richard J. Morton Evelyne Deery Martin J. Warren Nigel J. Robinson
author_sort	Tessa R. Young
title	Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
title_short	Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
title_full	Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
title_fullStr	Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
title_full_unstemmed	Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII
title_sort	calculating metalation in cells reveals cobw acquires coii for vitamin b12 biosynthesis while related proteins prefer znii
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47a874e4fffe4f87807b18d00ce0daa2
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Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII

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