Regulation of cancer epigenomes with a histone-binding synthetic transcription factor

Cancer: Engineered protein switches on silenced genes An engineered protein that manipulates DNA-protein packaging in cancer cells could offer a powerful new approach to treating tumors. Karmella Haynes and colleagues from Arizona State University in Tempe, USA, designed a protein that can recognize...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David B. Nyer, Rene M. Daer, Daniel Vargas, Caroline Hom, Karmella A. Haynes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/47a99ef04ae84b7d9b759df37b2ca108
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:47a99ef04ae84b7d9b759df37b2ca108
record_format	dspace
spelling	oai:doaj.org-article:47a99ef04ae84b7d9b759df37b2ca1082021-12-02T11:42:12ZRegulation of cancer epigenomes with a histone-binding synthetic transcription factor10.1038/s41525-016-0002-32056-7944https://doaj.org/article/47a99ef04ae84b7d9b759df37b2ca1082017-01-01T00:00:00Zhttps://doi.org/10.1038/s41525-016-0002-3https://doaj.org/toc/2056-7944Cancer: Engineered protein switches on silenced genes An engineered protein that manipulates DNA-protein packaging in cancer cells could offer a powerful new approach to treating tumors. Karmella Haynes and colleagues from Arizona State University in Tempe, USA, designed a protein that can recognize chemical tags on DNA-wound chromatin structures where gene activity is being silenced and then reactivate those epigenetically repressed genes. In previous work, Haynes’ team showed how this “Polycomb-based transcription factor” could stimulate gene expression at two silenced genes in one cancer cell line. Now, working in three different cancer cell types, the researchers demonstrate that treatment with this engineered protein increases the expression levels of many genes across the genome involved in developmental regulation and tumor suppression. If the engineered protein works specifically in cancer cells, while leaving healthy tissue alone, it could prove beneficial for patients.David B. NyerRene M. DaerDaniel VargasCaroline HomKarmella A. HaynesNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 David B. Nyer Rene M. Daer Daniel Vargas Caroline Hom Karmella A. Haynes Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
description	Cancer: Engineered protein switches on silenced genes An engineered protein that manipulates DNA-protein packaging in cancer cells could offer a powerful new approach to treating tumors. Karmella Haynes and colleagues from Arizona State University in Tempe, USA, designed a protein that can recognize chemical tags on DNA-wound chromatin structures where gene activity is being silenced and then reactivate those epigenetically repressed genes. In previous work, Haynes’ team showed how this “Polycomb-based transcription factor” could stimulate gene expression at two silenced genes in one cancer cell line. Now, working in three different cancer cell types, the researchers demonstrate that treatment with this engineered protein increases the expression levels of many genes across the genome involved in developmental regulation and tumor suppression. If the engineered protein works specifically in cancer cells, while leaving healthy tissue alone, it could prove beneficial for patients.
format	article
author	David B. Nyer Rene M. Daer Daniel Vargas Caroline Hom Karmella A. Haynes
author_facet	David B. Nyer Rene M. Daer Daniel Vargas Caroline Hom Karmella A. Haynes
author_sort	David B. Nyer
title	Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
title_short	Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
title_full	Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
title_fullStr	Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
title_full_unstemmed	Regulation of cancer epigenomes with a histone-binding synthetic transcription factor
title_sort	regulation of cancer epigenomes with a histone-binding synthetic transcription factor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/47a99ef04ae84b7d9b759df37b2ca108
work_keys_str_mv	AT davidbnyer regulationofcancerepigenomeswithahistonebindingsynthetictranscriptionfactor AT renemdaer regulationofcancerepigenomeswithahistonebindingsynthetictranscriptionfactor AT danielvargas regulationofcancerepigenomeswithahistonebindingsynthetictranscriptionfactor AT carolinehom regulationofcancerepigenomeswithahistonebindingsynthetictranscriptionfactor AT karmellaahaynes regulationofcancerepigenomeswithahistonebindingsynthetictranscriptionfactor
_version_	1718395337929916416

Regulation of cancer epigenomes with a histone-binding synthetic transcription factor

Ejemplares similares