Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not completely understood as intermediate states remain poorly characterized by structural approaches. In a previous study on the prototypic bacterial proton-gated cha...

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Autores principales: Solène N Lefebvre, Antoine Taly, Anaïs Menny, Karima Medjebeur, Pierre-Jean Corringer
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
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Acceso en línea:https://doaj.org/article/47b01ac4ec284c219fa466c9ed105727
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