Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility

Sensory conflicts leading to motion sickness can occur not only between but also within sensory modalities. The vestibular organs are located in both left and right inner ears, and their misalignment can be a source of self-motion related sensory conflicts. In the current study, using inner ear magn...

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Autores principales:	Takumi Harada, Tomoko Sugawara, Taeko Ito, Yoshiro Wada, Masaki Fukunaga, Norihiro Sadato, Stephen K. Larroque, Athena Demertzi, Steven Laureys, Hiroyuki Sakai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	motion sickness vestibular morphology asymmetry inner ear resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/47b2a03908c44718aa10cce1ca7f4cf3
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spelling	oai:doaj.org-article:47b2a03908c44718aa10cce1ca7f4cf32021-11-04T08:11:36ZVestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility1662-453X10.3389/fnins.2021.763040https://doaj.org/article/47b2a03908c44718aa10cce1ca7f4cf32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.763040/fullhttps://doaj.org/toc/1662-453XSensory conflicts leading to motion sickness can occur not only between but also within sensory modalities. The vestibular organs are located in both left and right inner ears, and their misalignment can be a source of self-motion related sensory conflicts. In the current study, using inner ear magnetic resonance imaging, we examined whether morphological asymmetry of the bilateral vestibular organs was associated with motion sickness susceptibility. The results showed a larger position asymmetry of bilateral vestibular organs in individuals with high rather than low susceptibility. In addition, vestibular position asymmetry was associated with reciprocal interaction (negative resting state functional connectivity) between vestibular and visuocortical regions in lowly, but not highly, susceptible individuals. In conclusion, these findings suggest that vestibular morphological asymmetry can be a source of sensory conflicts in individuals with dysfunctional reciprocal visuo-vestibular interactions, a putative neural mechanism for resolving sensory conflicts.Takumi HaradaTomoko SugawaraTaeko ItoYoshiro WadaMasaki FukunagaNorihiro SadatoStephen K. LarroqueAthena DemertziSteven LaureysHiroyuki SakaiFrontiers Media S.A.articlemotion sicknessvestibularmorphologyasymmetryinner earresting stateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	motion sickness vestibular morphology asymmetry inner ear resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	motion sickness vestibular morphology asymmetry inner ear resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Takumi Harada Tomoko Sugawara Taeko Ito Yoshiro Wada Masaki Fukunaga Norihiro Sadato Stephen K. Larroque Athena Demertzi Steven Laureys Hiroyuki Sakai Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility
description	Sensory conflicts leading to motion sickness can occur not only between but also within sensory modalities. The vestibular organs are located in both left and right inner ears, and their misalignment can be a source of self-motion related sensory conflicts. In the current study, using inner ear magnetic resonance imaging, we examined whether morphological asymmetry of the bilateral vestibular organs was associated with motion sickness susceptibility. The results showed a larger position asymmetry of bilateral vestibular organs in individuals with high rather than low susceptibility. In addition, vestibular position asymmetry was associated with reciprocal interaction (negative resting state functional connectivity) between vestibular and visuocortical regions in lowly, but not highly, susceptible individuals. In conclusion, these findings suggest that vestibular morphological asymmetry can be a source of sensory conflicts in individuals with dysfunctional reciprocal visuo-vestibular interactions, a putative neural mechanism for resolving sensory conflicts.
format	article
author	Takumi Harada Tomoko Sugawara Taeko Ito Yoshiro Wada Masaki Fukunaga Norihiro Sadato Stephen K. Larroque Athena Demertzi Steven Laureys Hiroyuki Sakai
author_facet	Takumi Harada Tomoko Sugawara Taeko Ito Yoshiro Wada Masaki Fukunaga Norihiro Sadato Stephen K. Larroque Athena Demertzi Steven Laureys Hiroyuki Sakai
author_sort	Takumi Harada
title	Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility
title_short	Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility
title_full	Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility
title_fullStr	Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility
title_full_unstemmed	Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility
title_sort	vestibular morphological asymmetry associated with motion sickness susceptibility
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/47b2a03908c44718aa10cce1ca7f4cf3
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Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility

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