NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING

The review deals with modern ideas of neuroimmunoendocrine regulation of physiological and pathophysiological processes in skin. The present data are provided which indicate to composite mechanisms of intercellular interactions in complex regulating systems (nervous, immune, endocrine) acting at the...

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Autores principales:	O. A. Bashkina, M. A. Samotrueva, A. K. Azhikova, L. R. Paknnova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	neuroimmunological interactions skin pathological process reparative regeneration Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/47b2ba1740d5437c96d92f5120b96696
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spelling	oai:doaj.org-article:47b2ba1740d5437c96d92f5120b966962021-11-18T08:03:48ZNEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING1563-06252313-741X10.15789/1563-0625-2019-5-807-820https://doaj.org/article/47b2ba1740d5437c96d92f5120b966962019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1659https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe review deals with modern ideas of neuroimmunoendocrine regulation of physiological and pathophysiological processes in skin. The present data are provided which indicate to composite mechanisms of intercellular interactions in complex regulating systems (nervous, immune, endocrine) acting at the level of skin in normal conditions, as well during the posttraumatic period. We describe different modes for participation of endocrine and nervous systems in immunologically induced skin inflammation. The data are provided confirming localization of adrenergic receptors on membranes of immunocompetent cells and leukocytes, on regulatory effects of hypothalamus upon immune functions, about multidirectional actions upon inflammation of sympathetic and parasympathetic nervous system etc.There are sufficient data on promotion of pathophysiological changes and reconstitution processes in the skin due to effects of local immune cells and bioactive substances expressed by them. The course of skin wound regeneration depend on the type of damage, degree and a phase of healing process. Posttraumatic reparative potential of skin is often limited by the infectious processes initiated by local microflora, products of cell disintegration and necrotic tissues. The cause-effect relationship is proven by arising inflammation which is implemented by inclusion of immune protection responses. The increased necrotic area and suppuration of the wound occurs die to inhibition of system of the phagocytizing macrophages. However, activation of this system brings about formation of the connective tissue capsule around the inflammation focus within early terms.We also discuss the issues of reparative skin regeneration which of great medico-social value, in connection with considerable prevalence of traumatic events and their social consequences, followed by expressed cosmetic defects. Evolving neurocognitive problems lead to decreased quality of the patient’s life, development of social disadaptation and further deprivation. The role of nervous system and psychological frustration in genesis of skin manifestations requires future development of the modern scientific direction, i.e., psychodermatology.Understanding of molecular mechanisms regulating the neuroimmunocutaneous interactions offers new prospectives in treatment of some skin diseases, as well as activation of the damaged skin recovery. According to the data presented in the review article, one may conclude on relevance of further studies on reparative potential of skin under interactions of homeostatic regulatory systems.O. A. BashkinaM. A. SamotruevaA. K. AzhikovaL. R. PaknnovaSPb RAACIarticleneuroimmunological interactionsskinpathological processreparative regenerationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 807-820 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	neuroimmunological interactions skin pathological process reparative regeneration Immunologic diseases. Allergy RC581-607
spellingShingle	neuroimmunological interactions skin pathological process reparative regeneration Immunologic diseases. Allergy RC581-607 O. A. Bashkina M. A. Samotrueva A. K. Azhikova L. R. Paknnova NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING
description	The review deals with modern ideas of neuroimmunoendocrine regulation of physiological and pathophysiological processes in skin. The present data are provided which indicate to composite mechanisms of intercellular interactions in complex regulating systems (nervous, immune, endocrine) acting at the level of skin in normal conditions, as well during the posttraumatic period. We describe different modes for participation of endocrine and nervous systems in immunologically induced skin inflammation. The data are provided confirming localization of adrenergic receptors on membranes of immunocompetent cells and leukocytes, on regulatory effects of hypothalamus upon immune functions, about multidirectional actions upon inflammation of sympathetic and parasympathetic nervous system etc.There are sufficient data on promotion of pathophysiological changes and reconstitution processes in the skin due to effects of local immune cells and bioactive substances expressed by them. The course of skin wound regeneration depend on the type of damage, degree and a phase of healing process. Posttraumatic reparative potential of skin is often limited by the infectious processes initiated by local microflora, products of cell disintegration and necrotic tissues. The cause-effect relationship is proven by arising inflammation which is implemented by inclusion of immune protection responses. The increased necrotic area and suppuration of the wound occurs die to inhibition of system of the phagocytizing macrophages. However, activation of this system brings about formation of the connective tissue capsule around the inflammation focus within early terms.We also discuss the issues of reparative skin regeneration which of great medico-social value, in connection with considerable prevalence of traumatic events and their social consequences, followed by expressed cosmetic defects. Evolving neurocognitive problems lead to decreased quality of the patient’s life, development of social disadaptation and further deprivation. The role of nervous system and psychological frustration in genesis of skin manifestations requires future development of the modern scientific direction, i.e., psychodermatology.Understanding of molecular mechanisms regulating the neuroimmunocutaneous interactions offers new prospectives in treatment of some skin diseases, as well as activation of the damaged skin recovery. According to the data presented in the review article, one may conclude on relevance of further studies on reparative potential of skin under interactions of homeostatic regulatory systems.
format	article
author	O. A. Bashkina M. A. Samotrueva A. K. Azhikova L. R. Paknnova
author_facet	O. A. Bashkina M. A. Samotrueva A. K. Azhikova L. R. Paknnova
author_sort	O. A. Bashkina
title	NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING
title_short	NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING
title_full	NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING
title_fullStr	NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING
title_full_unstemmed	NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING
title_sort	neuroimmunoendocrine regulation of the skin functioning
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/47b2ba1740d5437c96d92f5120b96696
work_keys_str_mv	AT oabashkina neuroimmunoendocrineregulationoftheskinfunctioning AT masamotrueva neuroimmunoendocrineregulationoftheskinfunctioning AT akazhikova neuroimmunoendocrineregulationoftheskinfunctioning AT lrpaknnova neuroimmunoendocrineregulationoftheskinfunctioning
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NEUROIMMUNOENDOCRINE REGULATION OF THE SKIN FUNCTIONING

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